Profen and Spleen disorder - a phase IV clinical study of FDA data

Summary:

Spleen disorder is reported as a side effect among people who take Profen (ibuprofen), especially for people who are male, 50-59 old, also take Jakafi, and have Primary myelofibrosis.

The phase IV clinical study analyzes which people have Spleen disorder when taking Profen. It is created by eHealthMe based on reports of 239,319 people who have side effects when taking Profen from the FDA, and is updated regularly.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

What is Spleen disorder?

Spleen disorder (disease of spleen) is found to be associated with 382 drugs and 410 conditions by eHealthMe. Check the latest studies of Spleen disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

239,319 people reported to have side effects when taking Profen.
Among them, 56 people (0.02%) have Spleen disorder.

Among these 56 people:

What is the gender of people who have Spleen disorder when taking Profen? *

female: 46.34 %
male: 53.66 %

What is the age of people who have Spleen disorder when taking Profen? *

What are other drugs people take besides Profen? *

What are other side effects people have besides Spleen disorder? *

Liver Disorder (liver diseases): 21 people, 37.50%
Fatigue (feeling of tiredness): 20 people, 35.71%
Joint Pain: 18 people, 32.14%
Thrombocytopenia (decrease of platelets in blood): 15 people, 26.79%
Upper Respiratory Tract Infection: 13 people, 23.21%
Headache (pain in head): 13 people, 23.21%
Weakness: 12 people, 21.43%
Anaemia (lack of blood): 12 people, 21.43%
Haemoglobin Decreased: 11 people, 19.64%
Pain In Extremity: 11 people, 19.64%

What are the existing conditions these people have? *

Primary Myelofibrosis (primary disorder of the bone marrow): 21 people, 37.50%
Gout (uric acid crystals building up in the body): 6 people, 10.71%
Stress And Anxiety: 4 people, 7.14%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 7.14%
High Blood Pressure: 4 people, 7.14%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.36%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 5.36%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 2 people, 3.57%
Cardiac Disorder: 2 people, 3.57%
Type 2 Diabetes: 2 people, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Profen and have Spleen disorder?

- Check whether Spleen disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Profen:

Profen (245,311 reports)

Spleen disorder treatments and more:

Spleen disorder (2,370 reports)

Browse all side effects of Profen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spleen disorder:

Spleen disorder (382 drugs)

Browse all the conditions that are associated with Spleen disorder:

Spleen disorder (410 conditions)

Related publications that referenced our studies

Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .
Moslim MA, Sodeman TC, Nawras AT, "A Case of Suggested Ibuprofen-Induced Acute Pancreatitis", American journal of therapeutics, 2016 Nov .

How the study uses the data?

The study uses data from the FDA. It is based on ibuprofen (the active ingredients of Profen) and Profen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.