Prometrium and Heart palpitations - a phase IV clinical study of FDA data

Summary:

Heart palpitations is reported as a side effect among people who take Prometrium (progesterone), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Synthroid, and have High blood pressure.

The phase IV clinical study analyzes which people have Heart palpitations when taking Prometrium. It is created by eHealthMe based on reports of 5,562 people who have side effects when taking Prometrium from the FDA, and is updated regularly.

What is Prometrium?

Prometrium has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 5,980 Prometrium users. Check the latest studies of Prometrium.

What is Heart palpitations?

Heart palpitations (feelings or sensations that your heart is pounding or racing) is found to be associated with 2,441 drugs and 3,638 conditions by eHealthMe. Check the latest studies of Heart palpitations.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

5,562 people reported to have side effects when taking Prometrium.
Among them, 93 people (1.67%) have Heart palpitations.

Could Prometrium cause Heart palpitations?

Among these 93 people:

How long have people been on Prometrium when they have Heart palpitations? *

What is the gender of people who have Heart palpitations when taking Prometrium? *

female: 98.9 %
male: 1.1 %

What is the age of people who have Heart palpitations when taking Prometrium? *

What are other drugs people take besides Prometrium? *

What are other side effects people have besides Heart palpitations? *

Stress And Anxiety: 35 people, 37.63%
High Blood Pressure: 30 people, 32.26%
Headache (pain in head): 30 people, 32.26%
Dyspnea (difficult or laboured breathing): 30 people, 32.26%
Nausea (feeling of having an urge to vomit): 23 people, 24.73%
Chest Pain: 21 people, 22.58%
Dizziness: 17 people, 18.28%
Throat Tightness: 17 people, 18.28%
Skin Blushing/flushing (a sudden reddening of the face, neck): 17 people, 18.28%
Sensation Of Foreign Body: 16 people, 17.20%

What are the existing conditions these people have? *

High Blood Pressure: 19 people, 20.43%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 18 people, 19.35%
Asthma: 16 people, 17.20%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 15 people, 16.13%
Postmenopause: 15 people, 16.13%
Folate Deficiency (lack of folic acid): 11 people, 11.83%
Restless Leg Syndrome (a powerful urge to move your legs): 11 people, 11.83%
Weakness: 10 people, 10.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 9.68%
Hypersensitivity: 8 people, 8.60%

* Approximation only. Some reports may have incomplete information.

Do you take Prometrium and have Heart palpitations?

- Check whether Heart palpitations is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prometrium:

Prometrium (5,980 reports)

Browse all side effects of Prometrium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart palpitations:

Heart palpitations (2,441 drugs)

Browse all the conditions that are associated with Heart palpitations:

Heart palpitations (3,638 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on progesterone (the active ingredients of Prometrium) and Prometrium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.