Protonix and Tumor lysis syndrome - a phase IV clinical study of FDA data

Summary:

Tumor lysis syndrome is reported as a side effect among people who take Protonix (pantoprazole sodium), especially for people who are male, 60+ old, also take Acyclovir, and have Oesophageal carcinoma.

The phase IV clinical study analyzes which people have Tumor lysis syndrome when taking Protonix. It is created by eHealthMe based on reports of 130,073 people who have side effects when taking Protonix from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

What is Tumor lysis syndrome?

Tumor lysis syndrome is found to be associated with 613 drugs and 843 conditions by eHealthMe. Check the latest studies of Tumor lysis syndrome.

On Aug, 04, 2026

130,073 people reported to have side effects when taking Protonix.
Among them, 34 people (0.03%) have Tumor lysis syndrome.

Could Protonix cause Tumor lysis syndrome?

Among these 34 people:

What is the gender of people who have Tumor lysis syndrome when taking Protonix? *

female: 35.29 %
male: 64.71 %

What is the age of people who have Tumor lysis syndrome when taking Protonix? *

What are other drugs people take besides Protonix? *

What are other side effects people have besides Tumor lysis syndrome? *

Acute Kidney Failure: 11 people, 32.35%
Fever: 7 people, 20.59%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 7 people, 20.59%
Generalised Oedema (swelling all over the body): 6 people, 17.65%
Hypotension (abnormally low blood pressure): 6 people, 17.65%
Nephropathy Toxic (damage to kidney due to toxins): 5 people, 14.71%
Hyperkalemia (damage to or disease of the kidney): 5 people, 14.71%
Agitation (state of anxiety or nervous excitement): 5 people, 14.71%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 4 people, 11.76%
Escherichia Infection (bacterial infection by escherichia coli): 4 people, 11.76%

What are the existing conditions these people have? *

Oesophageal Carcinoma (cancer tumour of oesophagus): 5 people, 14.71%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 11.76%
Multiple Myeloma (cancer of the plasma cells): 4 people, 11.76%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 8.82%
Nausea And Vomiting: 2 people, 5.88%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.88%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 5.88%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 5.88%
Nausea (feeling of having an urge to vomit): 2 people, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have Tumor lysis syndrome?

- Check whether Tumor lysis syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protonix:

Protonix (132,659 reports)

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tumor lysis syndrome:

Tumor lysis syndrome (613 drugs)

Browse all the conditions that are associated with Tumor lysis syndrome:

Tumor lysis syndrome (843 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.