Rabeprazole and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Rabeprazole (rabeprazole sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Metoclopramide, and have Impaired gastric emptying.

The phase IV clinical study analyzes which people have C. diff when taking Rabeprazole. It is created by eHealthMe based on reports of 31,196 people who have side effects when taking Rabeprazole from the FDA, and is updated regularly.

What is Rabeprazole?

Rabeprazole has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 31,686 Rabeprazole users. Check the latest studies of Rabeprazole.

What is C. diff?

C. diff is found to be associated with 1,626 drugs and 1,768 conditions by eHealthMe. Check the latest studies of C. diff.

On Nov, 25, 2025

31,196 people reported to have side effects when taking Rabeprazole.
Among them, 49 people (0.16%) have C. diff.

Among these 49 people:

How long have people been on Rabeprazole when they have C. diff? *

What is the gender of people who have C. diff when taking Rabeprazole? *

female: 60.47 %
male: 39.53 %

What is the age of people who have C. diff when taking Rabeprazole? *

What are other drugs people take besides Rabeprazole? *

Metoclopramide: 11 people, 22.45%
Mesalamine: 10 people, 20.41%
Valsartan: 10 people, 20.41%
Sertraline Hydrochloride: 9 people, 18.37%
Dexamethasone: 8 people, 16.33%
Duragesic-100: 7 people, 14.29%
Acyclovir: 6 people, 12.24%
Velcade: 6 people, 12.24%
Cordarone: 6 people, 12.24%
Amlodipine: 5 people, 10.20%

What are other side effects people have besides C. diff? *

Acute Kidney Failure: 11 people, 22.45%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 10 people, 20.41%
Overdose: 10 people, 20.41%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 10 people, 20.41%
Diarrhea: 10 people, 20.41%
Haemoglobin Decreased: 9 people, 18.37%
Fever: 8 people, 16.33%
Pneumonia: 8 people, 16.33%
Bundle Branch Block Left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle): 8 people, 16.33%
Dehydration (dryness resulting from the removal of water): 8 people, 16.33%

What are the existing conditions these people have? *

Impaired Gastric Emptying: 9 people, 18.37%
Multiple Myeloma (cancer of the plasma cells): 8 people, 16.33%
Pain: 7 people, 14.29%
Arrhythmias (irregular heartbeat): 6 people, 12.24%
High Blood Pressure: 5 people, 10.20%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 10.20%
Stress And Anxiety: 4 people, 8.16%
Indigestion: 4 people, 8.16%
Depression: 4 people, 8.16%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

Do you take Rabeprazole and have C. diff?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rabeprazole:

Rabeprazole (31,686 reports)

C. diff treatments and more:

C. diff (13,844 reports)

Browse all side effects of Rabeprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with C. diff:

C. diff (1,626 drugs)

Browse all the conditions that are associated with C. diff:

C. diff (1,768 conditions)

Drugs similar to Rabeprazole and C. diff :

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium (the active ingredients of Rabeprazole) and Rabeprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.