Nexium and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Nexium (esomeprazole magnesium), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Lasix, and have Multiple myeloma.

The phase IV clinical study analyzes which people have C. diff when taking Nexium. It is created by eHealthMe based on reports of 240,870 people who have side effects when taking Nexium from the FDA, and is updated regularly.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,675 Nexium users. Check the latest studies of Nexium.

What is C. diff?

C. diff is found to be associated with 1,645 drugs and 1,766 conditions by eHealthMe. Check the latest studies of C. diff.

On Jul, 23, 2025

240,870 people reported to have side effects when taking Nexium.
Among them, 304 people (0.13%) have C. diff.

Among these 304 people:

How long have people been on Nexium when they have C. diff? *

What is the gender of people who have C. diff when taking Nexium? *

female: 65.85 %
male: 34.15 %

What is the age of people who have C. diff when taking Nexium? *

What are other drugs people take besides Nexium? *

What are other side effects people have besides C. diff? *

Diarrhea: 61 people, 20.07%
Acute Kidney Failure: 58 people, 19.08%
Weakness: 52 people, 17.11%
Fever: 46 people, 15.13%
Pneumonia: 45 people, 14.80%
Urinary Tract Infection: 44 people, 14.47%
Anaemia (lack of blood): 44 people, 14.47%
Pain: 43 people, 14.14%
Stress And Anxiety: 40 people, 13.16%
Depression: 39 people, 12.83%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 40 people, 13.16%
Pain: 37 people, 12.17%
High Blood Pressure: 34 people, 11.18%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 31 people, 10.20%
Stress And Anxiety: 23 people, 7.57%
High Blood Cholesterol: 17 people, 5.59%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 17 people, 5.59%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 17 people, 5.59%
Insomnia (sleeplessness): 15 people, 4.93%
Nausea (feeling of having an urge to vomit): 15 people, 4.93%

* Approximation only. Some reports may have incomplete information.

Do you take Nexium and have C. diff?

- Check whether C. diff is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nexium:

Nexium (245,675 reports)

C. diff treatments and more:

C. diff (13,844 reports)

Common Nexium side effects:

Browse all side effects of Nexium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with C. diff:

Browse all the drugs that are associated with C. diff:

C. diff (1,645 drugs)

Common conditions associated with C. diff:

Plasmacytoma of bone: 814 reports
Hypertension: 750 reports
Acute lymphocytic leukemia (all): 516 reports
Alternative medicine - pain relief: 482 reports
Regional enteritis: 454 reports
Urinary tract infection: 411 reports
Multiple sclerosis: 348 reports
Colitis ulcerative: 343 reports
Ra: 332 reports
Osteoporosis: 322 reports

Browse all the conditions that are associated with C. diff:

C. diff (1,766 conditions)

Drugs similar to Nexium and C. diff :

Related publications that referenced our studies

Dr. Anthony Wong, "Esomeprazole and gynaecomastia in obese adults", WHO pharmaceuticals newsletter: 2019, No. 2, 2019 Jan .
Dr. Anthony Wong, "Esomeprazole and gynaecomastia in obese adults", WHO pharmaceuticals newsletter: 2019, No. 2, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on esomeprazole magnesium (the active ingredients of Nexium) and Nexium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.