Protonix and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Protonix (pantoprazole sodium), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Zofran, and have Multiple myeloma.

The phase IV clinical study analyzes which people have C. diff when taking Protonix. It is created by eHealthMe based on reports of 130,073 people who have side effects when taking Protonix from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,651 Protonix users. Check the latest studies of Protonix.

What is C. diff?

C. diff is found to be associated with 1,638 drugs and 1,768 conditions by eHealthMe. Check the latest studies of C. diff.

On Oct, 20, 2025

130,073 people reported to have side effects when taking Protonix.
Among them, 311 people (0.24%) have C. diff.

Among these 311 people:

How long have people been on Protonix when they have C. diff? *

What is the gender of people who have C. diff when taking Protonix? *

female: 56.51 %
male: 43.49 %

What is the age of people who have C. diff when taking Protonix? *

What are other drugs people take besides Protonix? *

What are other side effects people have besides C. diff? *

Weakness: 108 people, 34.73%
Pneumonia: 104 people, 33.44%
Diarrhea: 91 people, 29.26%
Dyspnea (difficult or laboured breathing): 82 people, 26.37%
Fever: 74 people, 23.79%
Pleural Effusion (water on the lungs): 69 people, 22.19%
Anaemia (lack of blood): 69 people, 22.19%
Urinary Tract Infection: 69 people, 22.19%
Abdominal Pain: 68 people, 21.86%
Hypotension (abnormally low blood pressure): 67 people, 21.54%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 66 people, 21.22%
Pain: 33 people, 10.61%
High Blood Pressure: 26 people, 8.36%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 25 people, 8.04%
Nausea (feeling of having an urge to vomit): 17 people, 5.47%
Depression: 15 people, 4.82%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 12 people, 3.86%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 10 people, 3.22%
Stress And Anxiety: 10 people, 3.22%
Muscle Spasms (muscle contraction): 9 people, 2.89%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have C. diff?

- Check whether C. diff is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protonix:

Protonix (132,651 reports)

C. diff treatments and more:

C. diff (13,844 reports)

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with C. diff:

Browse all the drugs that are associated with C. diff:

C. diff (1,638 drugs)

Common conditions associated with C. diff:

Plasma cell dyscrasia: 814 reports
Blood pressure increased: 750 reports
Leukemia - acute childhood (all): 516 reports
Alternative medicine - pain relief: 482 reports
Crohns disease: 454 reports
Urinary tract infection: 411 reports
Ms hug: 348 reports
Inflammatory bowel disease - ulcerative colitis: 343 reports
Ra: 332 reports
Osteoporosis: 322 reports

Browse all the conditions that are associated with C. diff:

C. diff (1,768 conditions)

Drugs similar to Protonix and C. diff :

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.