Remicade and Synovial rupture - a phase IV clinical study of FDA data


We study 215,158 people who have side effects when taking Remicade. Synovial rupture is found, especially among people who are female, 60+ old, also take Methotrexate and have Memory loss.

The phase IV clinical study analyzes which people take Remicade and have Synovial rupture. It is created by eHealthMe based on reports from the FDA, and is updated regularly. You may use the study as a second opinion to make health care decisions.

Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Our original studies have been referenced on 700+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature.

On Sep, 28, 2023

215,158 people reported to have side effects when taking Remicade.
Among them, 11 people (0.01%) have Synovial rupture.

What is Remicade?

Remicade has active ingredients of infliximab. It is used in crohn's disease. Currently, eHealthMe is studying from 216,502 Remicade users.

What is Synovial rupture?

Synovial rupture (tear of synovial membrane of joint) is found to be associated with 280 drugs and 149 conditions by eHealthMe. Currently, we are studying 451 people who have Synovial rupture.

Number of Remicade and Synovial rupture reports submitted per year:

Could Remicade cause Synovial rupture?

Gender of people who have Synovial rupture when taking Remicade *:

  • female: 81.82 %
  • male: 18.18 %

Age of people who have Synovial rupture when taking Remicade *:

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 18.18 %
  • 50-59: 0.0 %
  • 60+: 81.82 %

Common drugs people take besides Remicade *:

  1. Methotrexate: 5 people, 45.45%
  2. Seroquel: 3 people, 27.27%
  3. Lortab: 3 people, 27.27%
  4. Effexor: 2 people, 18.18%
  5. Folic Acid: 2 people, 18.18%
  6. Fosamax: 2 people, 18.18%
  7. Warfarin Sodium: 2 people, 18.18%
  8. Lantus: 1 person, 9.09%
  9. Enbrel: 1 person, 9.09%
  10. Fluoxetine: 1 person, 9.09%

Common side effects people have besides Synovial rupture *:

  1. Joint Crepitation: 3 people, 27.27%
  2. Weakness: 3 people, 27.27%
  3. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 3 people, 27.27%
  4. Body Height Decreased: 3 people, 27.27%
  5. Hyperhidrosis (abnormally increased sweating): 3 people, 27.27%
  6. Hot Flush (sudden feelings of heat): 3 people, 27.27%
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 27.27%
  8. Fall: 3 people, 27.27%
  9. Erysipelas (bacterial skin infection): 2 people, 18.18%
  10. Mobility Decreased (ability to move is reduced): 2 people, 18.18%

Common conditions people have *:

  1. Pain: 3 people, 27.27%
  2. Memory Loss: 3 people, 27.27%
  3. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 9.09%
  4. Chest Pain: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Remicade and have Synovial rupture?

Check whether Synovial rupture is associated with a drug or a condition

How to use the study?

You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood.

Related studies

Remicade side effects by duration, gender and age:

Synovial rupture treatments and more:

All the drugs that are associated with Synovial rupture:

Common conditions associated with Synovial rupture:

All the conditions that are associated with Synovial rupture:

How the study uses the data?

The study uses data from the FDA. It is based on infliximab (the active ingredients of Remicade) and Remicade (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

Who is eHealthMe?

With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 700+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).


WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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