Rinvoq and Pathological fracture - a phase IV clinical study of FDA data

Summary:

Pathological fracture is reported as a side effect among people who take Rinvoq (upadacitinib), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Gabapentin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Pathological fracture when taking Rinvoq. It is created by eHealthMe based on reports of 47,330 people who have side effects when taking Rinvoq from the FDA, and is updated regularly.

What is Rinvoq?

Rinvoq has active ingredients of upadacitinib. eHealthMe is studying from 47,375 Rinvoq users. Check the latest studies of Rinvoq.

What is Pathological fracture?

Pathological fracture (broken bone caused by disease) is found to be associated with 837 drugs and 541 conditions by eHealthMe. Check the latest studies of Pathological fracture.

On Jul, 15, 2026

47,330 people reported to have side effects when taking Rinvoq.
Among them, 11 people (0.02%) have Pathological fracture.

$Could Rinvoq cause Pathological fracture?$

Among these 11 people:

How long have people been on Rinvoq when they have Pathological fracture? *

What is the gender of people who have Pathological fracture when taking Rinvoq? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Pathological fracture when taking Rinvoq? *

What are other drugs people take besides Rinvoq? *

Fluticasone Propionate: 2 people, 18.18%
Gabapentin: 2 people, 18.18%
Zofran: 1 person, 9.09%
Hydroxyzine: 1 person, 9.09%
Alprazolam: 1 person, 9.09%
Calcium: 1 person, 9.09%
Calcium Carbonate: 1 person, 9.09%
Celebrex: 1 person, 9.09%
Diclofenac: 1 person, 9.09%
Effexor: 1 person, 9.09%

What are other side effects people have besides Pathological fracture? *

Fall: 4 people, 36.36%
Osteoporosis (bones weak and more likely to break): 3 people, 27.27%
Spinal Osteoarthritis (joint cartilage loss in spine): 2 people, 18.18%
Spinal Fracture (fracture in one of vertebrae): 2 people, 18.18%
Pain: 2 people, 18.18%
Weight Loss: 1 person, 9.09%
Intervertebral Disc Degeneration (spinal disc degeneration): 1 person, 9.09%
Humerus Fracture (injury to the upper arm bone): 1 person, 9.09%
Groin Pain: 1 person, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 81.82%
Stress And Anxiety: 1 person, 9.09%
Spinal Stenosis (narrowing of spinal column): 1 person, 9.09%
Sleep Disorder: 1 person, 9.09%
Osteoporosis (bones weak and more likely to break): 1 person, 9.09%
Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 1 person, 9.09%
Neuralgia (pain in one or more nerves): 1 person, 9.09%
Multiple Allergies (allergy to multiple agents): 1 person, 9.09%
Migraine (headache): 1 person, 9.09%
Insomnia (sleeplessness): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Rinvoq and have Pathological fracture?

- Check whether Pathological fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rinvoq:

Rinvoq (47,375 reports)

Browse all side effects of Rinvoq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pathological fracture:

Pathological fracture (837 drugs)

Browse all the conditions that are associated with Pathological fracture:

Pathological fracture (541 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on upadacitinib (the active ingredients of Rinvoq) and Rinvoq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.