Rythmol and Liver function test abnormal - a phase IV clinical study of FDA data

Summary:

Liver function test abnormal is reported as a side effect among people who take Rythmol (propafenone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Warfarin Sodium, and have Pulmonary embolism.

The phase IV clinical study analyzes which people have Liver function test abnormal when taking Rythmol. It is created by eHealthMe based on reports of 3,422 people who have side effects when taking Rythmol from the FDA, and is updated regularly.

What is Rythmol?

Rythmol has active ingredients of propafenone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 3,638 Rythmol users. Check the latest studies of Rythmol.

What is Liver function test abnormal?

Liver function test abnormal is found to be associated with 1,497 drugs and 1,963 conditions by eHealthMe. Check the latest studies of Liver function test abnormal.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

3,422 people reported to have side effects when taking Rythmol.
Among them, 16 people (0.47%) have Liver function test abnormal.

Could Rythmol cause Liver function test abnormal?

Among these 16 people:

How long have people been on Rythmol when they have Liver function test abnormal? *

What is the gender of people who have Liver function test abnormal when taking Rythmol? *

female: 80 %
male: 20 %

What is the age of people who have Liver function test abnormal when taking Rythmol? *

What are other drugs people take besides Rythmol? *

What are other side effects people have besides Liver function test abnormal? *

Abdominal Pain: 5 people, 31.25%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 5 people, 31.25%
Cellulitis (infection under the skin): 4 people, 25.00%
International Normalised Ratio Increased: 4 people, 25.00%
Hyperkalemia (damage to or disease of the kidney): 4 people, 25.00%
Aspartate Aminotransferase Increased: 4 people, 25.00%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 4 people, 25.00%
Cardiac Failure Congestive: 4 people, 25.00%
Alanine Aminotransferase Increased: 3 people, 18.75%
Hypotension (abnormally low blood pressure): 3 people, 18.75%

What are the existing conditions these people have? *

Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 25.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 18.75%
Muscle Spasms (muscle contraction): 3 people, 18.75%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 18.75%
Hypokalemia (low potassium): 3 people, 18.75%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 12.50%
Intraocular Pressure Increased: 2 people, 12.50%
Dry Eyes (lack of adequate tears): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Rythmol and have Liver function test abnormal?

- Check whether Liver function test abnormal is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rythmol:

Rythmol (3,638 reports)

Browse all side effects of Rythmol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Liver function test abnormal:

Liver function test abnormal (1,497 drugs)

Browse all the conditions that are associated with Liver function test abnormal:

Liver function test abnormal (1,963 conditions)

Related publications that referenced our studies

Tesic D, Kostic M, Paunovic D, Jankovic SM, "Analysis of the cost–effectiveness of dronedarone versus amiodarone, propafenone, and sotalol in patients with atrial fibrillation: results for Serbia", Kardiologia Polska (Polish Heart Journal), 2016 Jan .
Tesic D, Kostic M, Paunovic D, Jankovic SM, "Analysis of the cost–effectiveness of dronedarone versus amiodarone, propafenone, and sotalol in patients with atrial fibrillation: results for Serbia", Kardiologia Polska (Polish Heart Journal), 2016 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on propafenone hydrochloride (the active ingredients of Rythmol) and Rythmol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.