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Seroquel and Hyperosmolar state - a phase IV clinical study of FDA data

Summary:

Hyperosmolar state is reported as a side effect among people who take Seroquel (quetiapine fumarate), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Zyprexa, and have Sleep disorder.

The phase IV clinical study analyzes which people have Hyperosmolar state when taking Seroquel. It is created by eHealthMe based on reports of 113,615 people who have side effects when taking Seroquel from the FDA, and is updated regularly.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.

What is Hyperosmolar state?

Hyperosmolar state (life-threatening emergency manifested by marked elevation of blood glucose) is found to be associated with 69 drugs and 258 conditions by eHealthMe. Check the latest studies of Hyperosmolar state.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

113,615 people reported to have side effects when taking Seroquel.
Among them, 16 people (0.01%) have Hyperosmolar state.

Could Seroquel cause Hyperosmolar state?

Among these 16 people:

How long have people been on Seroquel when they have Hyperosmolar state? *

  • < 1 month: 40 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 20 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 20 %
  • 5 - 10 years: 20 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyperosmolar state when taking Seroquel? *

  • female: 18.75 %
  • male: 81.25 %

What is the age of people who have Hyperosmolar state when taking Seroquel? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 18.75 %
  • 30-39: 0.0 %
  • 40-49: 37.5 %
  • 50-59: 37.5 %
  • 60+: 6.25 %

What are other drugs people take besides Seroquel? *

  1. Lorazepam: 5 people, 31.25%
  2. Zyprexa: 5 people, 31.25%
  3. Risperidone: 4 people, 25.00%
  4. Benztropine Mesylate: 4 people, 25.00%
  5. Thorazine: 3 people, 18.75%
  6. Toprol-Xl: 3 people, 18.75%
  7. Trilafon: 3 people, 18.75%
  8. Aspirin: 3 people, 18.75%
  9. Geodon: 3 people, 18.75%
  10. Citalopram Hydrobromide: 3 people, 18.75%

What are other side effects people have besides Hyperosmolar state? *

  1. Type 2 Diabetes: 10 people, 62.50%
  2. High Blood Cholesterol: 7 people, 43.75%
  3. Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 37.50%
  4. Diabetic Ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies): 5 people, 31.25%
  5. Diabetes: 5 people, 31.25%
  6. Diabetes Mellitus Inadequate Control: 4 people, 25.00%
  7. Dehydration (dryness resulting from the removal of water): 4 people, 25.00%
  8. Pancreatitis (inflammation of pancreas): 3 people, 18.75%
  9. High Blood Pressure: 3 people, 18.75%
  10. Weight Increased: 3 people, 18.75%

What are the existing conditions these people have? *

  1. Sleep Disorder: 5 people, 31.25%
  2. Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 4 people, 25.00%
  3. Stress And Anxiety: 3 people, 18.75%
  4. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 6.25%
  5. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 6.25%
  6. Neuralgia (pain in one or more nerves): 1 person, 6.25%
  7. Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 6.25%
  8. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 6.25%
  9. Breakthrough Pain: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Seroquel and have Hyperosmolar state?

- Check whether Hyperosmolar state is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Seroquel:

Hyperosmolar state treatments and more:

How severe was Hyperosmolar state and when was it recovered:

Expand to all the drugs that have ingredients of quetiapine fumarate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Seroquel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperosmolar state:

Browse all the conditions that are associated with Hyperosmolar state:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on quetiapine fumarate (the active ingredients of Seroquel) and Seroquel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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