Simvastatin and Aortic calcification - a phase IV clinical study of FDA data

Summary:

Aortic calcification is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Zometa, and have Prostate cancer.

The phase IV clinical study analyzes which people have Aortic calcification when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

What is Aortic calcification?

Aortic calcification (aortic calcification sign of heart valve disease) is found to be associated with 372 drugs and 384 conditions by eHealthMe. Check the latest studies of Aortic calcification.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 49 people (0.02%) have Aortic calcification.

Could Simvastatin cause Aortic calcification?

Among these 49 people:

How long have people been on Simvastatin when they have Aortic calcification? *

What is the gender of people who have Aortic calcification when taking Simvastatin? *

female: 45.83 %
male: 54.17 %

What is the age of people who have Aortic calcification when taking Simvastatin? *

What are other drugs people take besides Simvastatin? *

What are other side effects people have besides Aortic calcification? *

Fall: 25 people, 51.02%
Enlarged Heart: 25 people, 51.02%
Osteonecrosis Of Jaw (death of bone of jaw): 25 people, 51.02%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 23 people, 46.94%
Anaemia (lack of blood): 23 people, 46.94%
Fatigue (feeling of tiredness): 21 people, 42.86%
Rib Fracture: 19 people, 38.78%
Pain In Jaw: 19 people, 38.78%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 19 people, 38.78%
Weight Decreased: 18 people, 36.73%

What are the existing conditions these people have? *

Prostate Cancer: 10 people, 20.41%
Multiple Myeloma (cancer of the plasma cells): 8 people, 16.33%
Parkinson's Disease: 6 people, 12.24%
Abdominal Discomfort: 3 people, 6.12%
Stress And Anxiety: 3 people, 6.12%
Metastases To Bone (cancer spreads to bone): 3 people, 6.12%
Cardiac Disorder: 3 people, 6.12%
Osteoporosis (bones weak and more likely to break): 3 people, 6.12%
Bone Disorder: 2 people, 4.08%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 4.08%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Aortic calcification?

- Check whether Aortic calcification is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,970 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic calcification:

Aortic calcification (372 drugs)

Browse all the conditions that are associated with Aortic calcification:

Aortic calcification (384 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.