Simvastatin and Blue toe syndrome - a phase IV clinical study of FDA data

Summary:

Blue toe syndrome is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Fish Oil, and have Pain.

The phase IV clinical study analyzes which people have Blue toe syndrome when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

What is Blue toe syndrome?

Blue toe syndrome (blue toe syndrome is a lack of blood flow to the toes causing a blue discoloration) is found to be associated with 67 drugs and 187 conditions by eHealthMe. Check the latest studies of Blue toe syndrome.

On Jul, 07, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 16 people (0.01%) have Blue toe syndrome.

Could Simvastatin cause Blue toe syndrome?

Among these 16 people:

How long have people been on Simvastatin when they have Blue toe syndrome? *

What is the gender of people who have Blue toe syndrome when taking Simvastatin? *

female: 18.75 %
male: 81.25 %

What is the age of people who have Blue toe syndrome when taking Simvastatin? *

What are other drugs people take besides Simvastatin? *

Fish Oil: 6 people, 37.50%
Xanax: 5 people, 31.25%
Lisinopril: 5 people, 31.25%
Imodium: 5 people, 31.25%
Gilotrif: 5 people, 31.25%
Viagra: 4 people, 25.00%
Tramadol: 4 people, 25.00%
Doxycycline: 3 people, 18.75%
Meclizine Hydrochloride: 3 people, 18.75%
Meloxicam: 3 people, 18.75%

What are other side effects people have besides Blue toe syndrome? *

Joint Pain: 6 people, 37.50%
Back Pain: 6 people, 37.50%
Rashes (redness): 6 people, 37.50%
Nasopharyngitis (inflammation of the nasopharynx): 5 people, 31.25%
Diarrhea: 5 people, 31.25%
Pain In Extremity: 5 people, 31.25%
Dry Eyes (lack of adequate tears): 5 people, 31.25%
Dry Mouth: 5 people, 31.25%
Dry Skin: 5 people, 31.25%
Fatigue (feeling of tiredness): 5 people, 31.25%

What are the existing conditions these people have? *

Pain: 5 people, 31.25%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 12.50%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 12.50%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 6.25%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 6.25%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 6.25%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 6.25%
Oesophagitis (inflammation of oesophagus): 1 person, 6.25%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 1 person, 6.25%
Hepatitis C: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Blue toe syndrome?

- Check whether Blue toe syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,969 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Blue toe syndrome:

Blue toe syndrome (67 drugs)

Browse all the conditions that are associated with Blue toe syndrome:

Blue toe syndrome (187 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.