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Simvastatin and Cardiac discomfort - a phase IV clinical study of FDA data

Summary:

Cardiac discomfort is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Magnesium, and have Bronchitis.

The phase IV clinical study analyzes which people have Cardiac discomfort when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,970 Simvastatin users. Check the latest studies of Simvastatin.

What is Cardiac discomfort?

Cardiac discomfort is found to be associated with 236 drugs and 355 conditions by eHealthMe. Check the latest studies of Cardiac discomfort.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 43 people (0.02%) have Cardiac discomfort.

Could Simvastatin cause Cardiac discomfort?

Among these 43 people:

How long have people been on Simvastatin when they have Cardiac discomfort? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 50 %
  • 10+ years: 0.0 %

What is the gender of people who have Cardiac discomfort when taking Simvastatin? *

  • female: 40 %
  • male: 60 %

What is the age of people who have Cardiac discomfort when taking Simvastatin? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 42.86 %
  • 60+: 57.14 %

What are other drugs people take besides Simvastatin? *

  1. Magnesium: 16 people, 37.21%
  2. Aspirin: 15 people, 34.88%
  3. Omega-3 Fatty Acids: 14 people, 32.56%
  4. Vitamin D3: 14 people, 32.56%
  5. Pitavastatin Calcium: 12 people, 27.91%
  6. Ezetimibe: 11 people, 25.58%
  7. Garlic: 11 people, 25.58%
  8. Ticagrelor: 11 people, 25.58%
  9. Omeprazole: 11 people, 25.58%
  10. Amiodarone Hydrochloride: 11 people, 25.58%

What are other side effects people have besides Cardiac discomfort? *

  1. Dizziness: 23 people, 53.49%
  2. Muscle Aches (muscle pain): 23 people, 53.49%
  3. Hyperhidrosis (abnormally increased sweating): 23 people, 53.49%
  4. Dyspnea (difficult or laboured breathing): 21 people, 48.84%
  5. Nausea (feeling of having an urge to vomit): 20 people, 46.51%
  6. Arrhythmias (irregular heartbeat): 20 people, 46.51%
  7. Gait Disturbance: 19 people, 44.19%
  8. General Physical Health Deterioration (weak health status): 19 people, 44.19%
  9. Chest Pain: 19 people, 44.19%
  10. Heart Attack: 18 people, 41.86%

What are the existing conditions these people have? *

  1. Fever: 16 people, 37.21%
  2. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 16 people, 37.21%
  3. Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 3 people, 6.98%
  4. Cardiac Disorder: 2 people, 4.65%
  5. Itching: 2 people, 4.65%
  6. Depression: 2 people, 4.65%
  7. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 4.65%
  8. Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 4.65%
  9. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 2.33%
  10. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 2.33%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Cardiac discomfort?

- Check whether Cardiac discomfort is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Cardiac discomfort treatments and more:

How severe was Cardiac discomfort and when was it recovered:

Expand to all the drugs that have ingredients of simvastatin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cardiac discomfort:

Browse all the conditions that are associated with Cardiac discomfort:

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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