Simvastatin and Hypercoagulation - a phase IV clinical study of FDA data

Summary:

Hypercoagulation is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Pantoprazole, and have Idiopathic thrombocytopenic purpura.

The phase IV clinical study analyzes which people have Hypercoagulation when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,964 Simvastatin users. Check the latest studies of Simvastatin.

What is Hypercoagulation?

Hypercoagulation (increased tendency for clotting of the blood) is found to be associated with 421 drugs and 533 conditions by eHealthMe. Check the latest studies of Hypercoagulation.

On Jan, 16, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 37 people (0.01%) have Hypercoagulation.

Could Simvastatin cause Hypercoagulation?

Among these 37 people:

How long have people been on Simvastatin when they have Hypercoagulation? *

What is the gender of people who have Hypercoagulation when taking Simvastatin? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Hypercoagulation when taking Simvastatin? *

What are other drugs people take besides Simvastatin? *

What are other side effects people have besides Hypercoagulation? *

Pain In Extremity: 16 people, 43.24%
Hyperhidrosis (abnormally increased sweating): 13 people, 35.14%
Weakness: 13 people, 35.14%
Fatigue (feeling of tiredness): 12 people, 32.43%
Diarrhea: 11 people, 29.73%
Nausea And Vomiting: 11 people, 29.73%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 11 people, 29.73%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 11 people, 29.73%
Nausea (feeling of having an urge to vomit): 10 people, 27.03%
Back Pain: 10 people, 27.03%

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 7 people, 18.92%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 6 people, 16.22%
Malignant Melanoma (skin cancer rises from melancytes): 6 people, 16.22%
Cerebral Artery Occlusion (blockage of blood vessel of brain by fat or clot): 5 people, 13.51%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.81%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 8.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 8.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.41%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 5.41%
Diabetes: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Hypercoagulation?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,964 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercoagulation:

Hypercoagulation (421 drugs)

Browse all the conditions that are associated with Hypercoagulation:

Hypercoagulation (533 conditions)

Drugs similar to Simvastatin and Hypercoagulation :

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.