Simvastatin and Second primary malignancy - a phase IV clinical study of FDA data

Summary:

Second primary malignancy is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Lasix, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Second primary malignancy when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,964 Simvastatin users. Check the latest studies of Simvastatin.

What is Second primary malignancy?

Second primary malignancy (after getting cure a cancer, a new cancer development) is found to be associated with 579 drugs and 459 conditions by eHealthMe. Check the latest studies of Second primary malignancy.

On Jan, 10, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 100 people (0.04%) have Second primary malignancy.

Could Simvastatin cause Second primary malignancy?

Among these 100 people:

How long have people been on Simvastatin when they have Second primary malignancy? *

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What is the gender of people who have Second primary malignancy when taking Simvastatin? *

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What is the age of people who have Second primary malignancy when taking Simvastatin? *

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* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Second primary malignancy?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,964 reports)

Second primary malignancy treatments and more:

Second primary malignancy (9,955 reports)

How severe was Second primary malignancy and when was it recovered:

Second primary malignancy in Simvastatin

Expand to all the drugs that have ingredients of simvastatin:

Second primary malignancy and drugs with ingredients of simvastatin

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Simvastatin side effects:

Simvastatin side effect: Nausea (feeling of having an urge to vomit) (13,681 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Second primary malignancy:

Browse all the drugs that are associated with Second primary malignancy:

Second primary malignancy (579 drugs)

Common conditions associated with Second primary malignancy:

Chronic myeloid leukaemia: 1,287 reports
Myelofibrosis: 641 reports
Breast cancer: 633 reports
Breast cancer metastatic: 539 reports
Neuroendocrine tumor: 535 reports
Cancer - non-hodgkin's lymphoma: 489 reports
Hypertension: 440 reports
Carcinoid tumor: 360 reports
Multiple myeloma: 300 reports
Gastrointestinal stromal tumour: 277 reports

Browse all the conditions that are associated with Second primary malignancy:

Second primary malignancy (459 conditions)

Drugs similar to Simvastatin and Second primary malignancy :

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.