Simvastatin and Stroke in evolution - a phase IV clinical study of FDA data

Summary:

Stroke in evolution is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Xarelto, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Stroke in evolution when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,967 Simvastatin users. Check the latest studies of Simvastatin.

What is Stroke in evolution?

Stroke in evolution (unstable stage in stroke syndrome in which the blockage is present but the syndrome has not progressed to the stage of completed stroke) is found to be associated with 39 drugs and 78 conditions by eHealthMe. Check the latest studies of Stroke in evolution.

On Apr, 23, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 17 people (0.01%) have Stroke in evolution.

Could Simvastatin cause Stroke in evolution?

Among these 17 people:

How long have people been on Simvastatin when they have Stroke in evolution? *

What is the gender of people who have Stroke in evolution when taking Simvastatin? *

female: 17.65 %
male: 82.35 %

What is the age of people who have Stroke in evolution when taking Simvastatin? *

What are other drugs people take besides Simvastatin? *

What are other side effects people have besides Stroke in evolution? *

Cerebral Haemorrhage (bleeding within the brain): 8 people, 47.06%
Brain Stem Haemorrhage (bleeding into structures of brain stem): 6 people, 35.29%
Haemorrhagic Transformation Stroke (haemorrhages develop inside areas of ischemia): 4 people, 23.53%
Ischaemic Stroke (stroke; caused by an interruption in the flow of blood to the brain): 4 people, 23.53%
Hypoxic-Ischaemic Encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total): 3 people, 17.65%
Pneumonia Bacterial (pneumonia associated with bacterial infection): 3 people, 17.65%
Heart Attack: 3 people, 17.65%
Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 2 people, 11.76%
Haemorrhagic Stroke (stroke caused by the rupture of a blood vessel in the brain): 2 people, 11.76%
Glycosuria (excretion of glucose into the urine): 2 people, 11.76%

What are the existing conditions these people have? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 11 people, 64.71%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 64.71%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 6 people, 35.29%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Stroke in evolution?

- Check whether Stroke in evolution is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,967 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Stroke in evolution:

Stroke in evolution (39 drugs)

Browse all the conditions that are associated with Stroke in evolution:

Stroke in evolution (78 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.