Simvastatin and Trigeminal neuralgia - a phase IV clinical study of FDA data

Summary:

Trigeminal neuralgia is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Pregabalin, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Trigeminal neuralgia when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

What is Trigeminal neuralgia?

Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation) is found to be associated with 422 drugs and 754 conditions by eHealthMe. Check the latest studies of Trigeminal neuralgia.

On Jul, 06, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 100 people (0.04%) have Trigeminal neuralgia.

Could Simvastatin cause Trigeminal neuralgia?

Among these 100 people:

How long have people been on Simvastatin when they have Trigeminal neuralgia? *

What is the gender of people who have Trigeminal neuralgia when taking Simvastatin? *

female: 70.65 %
male: 29.35 %

What is the age of people who have Trigeminal neuralgia when taking Simvastatin? *

What are other drugs people take besides Simvastatin? *

What are other side effects people have besides Trigeminal neuralgia? *

Headache (pain in head): 24 people, 24.00%
Kidney Stones: 13 people, 13.00%
Renal Colic (renal pain): 13 people, 13.00%
Fatigue (feeling of tiredness): 13 people, 13.00%
Weight Decreased: 12 people, 12.00%
Dizziness: 11 people, 11.00%
Weakness: 10 people, 10.00%
Otitis (ear infection): 9 people, 9.00%
Drug Ineffective: 9 people, 9.00%
Asthma: 8 people, 8.00%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 15 people, 15.00%
Diabetes: 10 people, 10.00%
Pain: 9 people, 9.00%
Immunodeficiency Common Variable: 8 people, 8.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 8.00%
Heart Attack: 8 people, 8.00%
Neuropathy Peripheral (surface nerve damage): 7 people, 7.00%
Hyperlipidaemia (presence of excess lipids in the blood): 7 people, 7.00%
Multiple Myeloma (cancer of the plasma cells): 7 people, 7.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 7 people, 7.00%

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Trigeminal neuralgia?

- Check whether Trigeminal neuralgia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,969 reports)

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Trigeminal neuralgia:

Trigeminal neuralgia (422 drugs)

Browse all the conditions that are associated with Trigeminal neuralgia:

Trigeminal neuralgia (754 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.