Simvastatin and Weight gain - a phase IV clinical study of FDA data

Summary:

Weight gain is reported as a side effect among people who take Simvastatin (simvastatin), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Metformin, and have Diabetes.

The phase IV clinical study analyzes which people have Weight gain when taking Simvastatin. It is created by eHealthMe based on reports of 249,370 people who have side effects when taking Simvastatin from the FDA, and is updated regularly.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,967 Simvastatin users. Check the latest studies of Simvastatin.

What is Weight gain?

Weight gain is found to be associated with 3,309 drugs and 3,992 conditions by eHealthMe. Check the latest studies of Weight gain.

On Jan, 22, 2026

249,370 people reported to have side effects when taking Simvastatin.
Among them, 3,368 people (1.35%) have Weight gain.

Among these 3,368 people:

* Approximation only. Some reports may have incomplete information.

Do you take Simvastatin and have Weight gain?

- Check whether Weight gain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Simvastatin:

Simvastatin (256,967 reports)

Weight gain treatments and more:

Weight gain (279,365 reports)

How severe was Weight gain and when was it recovered:

Weight gain in Simvastatin

Expand to all the drugs that have ingredients of simvastatin:

Weight gain and drugs with ingredients of simvastatin (5,071 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Simvastatin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight gain:

Weight gain (3,309 drugs)

Browse all the conditions that are associated with Weight gain:

Weight gain (3,992 conditions)

Related publications that referenced our studies

Eslami Shahrbabaki M, Nasirian M, Eslami Shahrbabaki P, "Extreme Weight Gain due to Short-term Use of Low-dose Propranolol", Journal of Mazandaran University of Medical Sciences, 2015 Jan .
Eslami Shahrbabaki M, Nasirian M, Eslami Shahrbabaki P, "Extreme Weight Gain due to Short-term Use of Low-dose Propranolol", Journal of Mazandaran University of Medical Sciences, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on simvastatin (the active ingredients of Simvastatin) and Simvastatin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.