Sinemet and Ascites - a phase IV clinical study of FDA data

Summary:

Ascites is reported as a side effect among people who take Sinemet (carbidopa; levodopa), especially for people who are female, 60+ old, also take Vitamin B12, and have Pulmonary hypertension.

The phase IV clinical study analyzes which people have Ascites when taking Sinemet. It is created by eHealthMe based on reports of 28,351 people who have side effects when taking Sinemet from the FDA, and is updated regularly.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

What is Ascites?

Ascites (accumulation of fluid in the abdominal cavity) is found to be associated with 1,533 drugs and 2,031 conditions by eHealthMe. Check the latest studies of Ascites.

On Aug, 11, 2026

28,351 people reported to have side effects when taking Sinemet.
Among them, 42 people (0.15%) have Ascites.

Among these 42 people:

What is the gender of people who have Ascites when taking Sinemet? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Ascites when taking Sinemet? *

What are other drugs people take besides Sinemet? *

What are other side effects people have besides Ascites? *

Pleural Effusion (water on the lungs): 25 people, 59.52%
Hypotension (abnormally low blood pressure): 14 people, 33.33%
Fatigue (feeling of tiredness): 12 people, 28.57%
Weight Increased: 10 people, 23.81%
Liver Function Tests Nos Abnormal: 10 people, 23.81%
Weakness: 10 people, 23.81%
Oedema Peripheral (superficial swelling): 10 people, 23.81%
Dizziness: 10 people, 23.81%
Fainting (loss of consciousness and postural tone): 10 people, 23.81%
Pain: 10 people, 23.81%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 10 people, 23.81%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 14.29%
Oedema (fluid collection in tissue): 6 people, 14.29%
Stress And Anxiety: 4 people, 9.52%
Oedema Peripheral (superficial swelling): 3 people, 7.14%
Constipation: 3 people, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 7.14%
Metastatic Carcinoid Tumor: 3 people, 7.14%
Enlarged Prostate: 2 people, 4.76%
Depression: 2 people, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Sinemet and have Ascites?

- Check whether Ascites is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sinemet:

Sinemet (29,601 reports)

Ascites treatments and more:

Ascites (42,930 reports)

Browse all side effects of Sinemet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ascites:

Ascites (1,533 drugs)

Browse all the conditions that are associated with Ascites:

Ascites (2,031 conditions)

Related publications that referenced our studies

Rajsekhar P, Reddy MM, Vaddera S, Rajini G, Tikeli V, "A Rare Case of Vitamin B12 Deficiency with Ascites", Journal of clinical and diagnostic research: JCDR, 2014 Jan .
Rajsekhar P, Reddy MM, Vaddera S, Rajini G, Tikeli V, "A Rare Case of Vitamin B12 Deficiency with Ascites", Journal of clinical and diagnostic research: JCDR, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Sinemet) and Sinemet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.