Spironolactone and Dysphoria - a phase IV clinical study of FDA data

Summary:

Dysphoria is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Adcirca, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Dysphoria when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Dysphoria?

Dysphoria (generalized dissatisfaction with life) is found to be associated with 351 drugs and 534 conditions by eHealthMe. Check the latest studies of Dysphoria.

On Jul, 17, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 15 people (0.01%) have Dysphoria.

Among these 15 people:

How long have people been on Spironolactone when they have Dysphoria? *

What is the gender of people who have Dysphoria when taking Spironolactone? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Dysphoria when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Dysphoria? *

Diarrhea: 7 people, 46.67%
Dizziness: 7 people, 46.67%
Nausea (feeling of having an urge to vomit): 7 people, 46.67%
Urine Output Increased: 6 people, 40.00%
Pain In Jaw: 6 people, 40.00%
Chest Pain: 6 people, 40.00%
Dermatitis Contact (skin reaction (dermatitis) resulting from exposure to allergens): 6 people, 40.00%
Fever: 6 people, 40.00%
Type Iv Hypersensitivity Reaction (delayed type hypersensitivity as the reaction takes two to three days to develop): 6 people, 40.00%
Malaise (a feeling of general discomfort or uneasiness): 6 people, 40.00%

What are the existing conditions these people have? *

Thyroiditis Chronic (long lasting inflammation of thyroid gland): 6 people, 40.00%
Right Ventricular Failure (right half of the heart fails to work): 6 people, 40.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 40.00%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 6 people, 40.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 40.00%
Connective Tissue Disorder (any disease that has the connective tissues of the body): 5 people, 33.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 6.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 6.67%
Cardiac Failure: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Dysphoria?

- Check whether Dysphoria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Dysphoria treatments and more:

Dysphoria (5,565 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dysphoria:

Dysphoria (351 drugs)

Browse all the conditions that are associated with Dysphoria:

Dysphoria (534 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.