Spironolactone and Pitting oedema - a phase IV clinical study of FDA data

Summary:

Pitting oedema is reported as a side effect among people who take Spironolactone (spironolactone), especially for people who are male, 60+ old, also take Lasix, and have Carcinoid tumor.

The phase IV clinical study analyzes which people have Pitting oedema when taking Spironolactone. It is created by eHealthMe based on reports of 119,147 people who have side effects when taking Spironolactone from the FDA, and is updated regularly.

What is Spironolactone?

Spironolactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 122,947 Spironolactone users. Check the latest studies of Spironolactone.

What is Pitting oedema?

Pitting oedema (skin discoloration) is found to be associated with 246 drugs and 419 conditions by eHealthMe. Check the latest studies of Pitting oedema.

On Jul, 18, 2026

119,147 people reported to have side effects when taking Spironolactone.
Among them, 14 people (0.01%) have Pitting oedema.

Could Spironolactone cause Pitting oedema?

Among these 14 people:

What is the gender of people who have Pitting oedema when taking Spironolactone? *

female: 50 %
male: 50 %

What is the age of people who have Pitting oedema when taking Spironolactone? *

What are other drugs people take besides Spironolactone? *

What are other side effects people have besides Pitting oedema? *

Dyspnea (difficult or laboured breathing): 6 people, 42.86%
Nausea (feeling of having an urge to vomit): 6 people, 42.86%
Acute Kidney Failure: 5 people, 35.71%
Oedema Peripheral (superficial swelling): 4 people, 28.57%
Abdominal Distension: 3 people, 21.43%
Supraventricular Extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle): 3 people, 21.43%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 21.43%
Hypotension (abnormally low blood pressure): 3 people, 21.43%
Constipation: 3 people, 21.43%
Headache (pain in head): 3 people, 21.43%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.14%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 7.14%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 7.14%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.14%
Hepatic Neoplasm Malignant (liver cancer): 1 person, 7.14%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 7.14%
Depression: 1 person, 7.14%
Colon Cancer Stage Iv: 1 person, 7.14%
Chronic Renal Failure (kidney failure): 1 person, 7.14%
Carcinoid Tumor: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Spironolactone and have Pitting oedema?

- Check whether Pitting oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Spironolactone:

Spironolactone (122,947 reports)

Pitting oedema treatments and more:

Pitting oedema (1,300 reports)

Browse all side effects of Spironolactone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pitting oedema:

Pitting oedema (246 drugs)

Browse all the conditions that are associated with Pitting oedema:

Pitting oedema (419 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on spironolactone (the active ingredients of Spironolactone) and Spironolactone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.