Sprintec and Water retention - a phase IV clinical study of FDA data

Summary:

Water retention is reported as a side effect among people who take Sprintec (ethinyl estradiol; norgestimate), especially for people who are female, 30-39 old, also take Ambien, and have Headache.

The phase IV clinical study analyzes which people have Water retention when taking Sprintec. It is created by eHealthMe based on reports of 3,556 people who have side effects when taking Sprintec from the FDA, and is updated regularly.

What is Sprintec?

Sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 4,397 Sprintec users. Check the latest studies of Sprintec.

What is Water retention?

Water retention is found to be associated with 2,247 drugs and 2,421 conditions by eHealthMe. Check the latest studies of Water retention.

On Nov, 14, 2025

3,556 people reported to have side effects when taking Sprintec.
Among them, 17 people (0.48%) have Water retention.

Among these 17 people:

What is the gender of people who have Water retention when taking Sprintec? *

female: 100 %
male: 0.0 %

What is the age of people who have Water retention when taking Sprintec? *

What are other drugs people take besides Sprintec? *

What are other side effects people have besides Water retention? *

Joint Pain: 5 people, 29.41%
Rashes (redness): 5 people, 29.41%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 29.41%
Drug Ineffective: 4 people, 23.53%
Pain: 4 people, 23.53%
Temperature Regulation Disorder (body is unable to maintain temperature): 3 people, 17.65%
Swelling: 3 people, 17.65%
Stress And Anxiety: 3 people, 17.65%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 3 people, 17.65%
Dizziness: 3 people, 17.65%

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 17.65%
Mood Swings (an extreme or rapid change in mood): 3 people, 17.65%
Iron Deficiency Anaemia: 3 people, 17.65%
Headache (pain in head): 3 people, 17.65%
Sleep Disorder: 2 people, 11.76%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 2 people, 11.76%
Pain: 2 people, 11.76%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 11.76%
Muscle Spasms (muscle contraction): 2 people, 11.76%
Indigestion: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Sprintec and have Water retention?

- Check whether Water retention is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sprintec:

Sprintec (4,397 reports)

Water retention treatments and more:

Water retention (79,647 reports)

How severe was Water retention and when was it recovered:

Water retention in Sprintec

Expand to all the drugs that have ingredients of ethinyl estradiol; norgestimate:

Water retention and drugs with ingredients of ethinyl estradiol; norgestimate (33 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sprintec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Water retention:

Water retention (2,247 drugs)

Browse all the conditions that are associated with Water retention:

Water retention (2,421 conditions)

Drugs similar to Sprintec and Water retention :

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate (the active ingredients of Sprintec) and Sprintec (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.