Subutex and Peripheral ischaemia - a phase IV clinical study of FDA data

Summary:

Peripheral ischaemia is reported as a side effect among people who take Subutex (buprenorphine hydrochloride), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Oxazepam, and have Drug dependence.

The phase IV clinical study analyzes which people have Peripheral ischaemia when taking Subutex. It is created by eHealthMe based on reports of 8,309 people who have side effects when taking Subutex from the FDA, and is updated regularly.

What is Subutex?

Subutex has active ingredients of buprenorphine hydrochloride. It is often used in opiate withdrawal. eHealthMe is studying from 8,763 Subutex users. Check the latest studies of Subutex.

What is Peripheral ischaemia?

Peripheral ischaemia (impaired circulation to an extremity) is found to be associated with 574 drugs and 645 conditions by eHealthMe. Check the latest studies of Peripheral ischaemia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

8,309 people reported to have side effects when taking Subutex.
Among them, 21 people (0.25%) have Peripheral ischaemia.

Could Subutex cause Peripheral ischaemia?

Among these 21 people:

How long have people been on Subutex when they have Peripheral ischaemia? *

What is the gender of people who have Peripheral ischaemia when taking Subutex? *

female: 16.67 %
male: 83.33 %

What is the age of people who have Peripheral ischaemia when taking Subutex? *

What are other drugs people take besides Subutex? *

What are other side effects people have besides Peripheral ischaemia? *

Necrosis (the death of body tissue): 3 people, 14.29%
Extremity Necrosis (death of body tissue of arms and legs): 3 people, 14.29%
Drug Dependence: 3 people, 14.29%
Skin Discoloration - Bluish (bluish colour of skin): 3 people, 14.29%
Agitation (state of anxiety or nervous excitement): 2 people, 9.52%
Death: 2 people, 9.52%
Hypotension (abnormally low blood pressure): 2 people, 9.52%
Hepatitis C Antibody Positive: 2 people, 9.52%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 2 people, 9.52%
Gangrene (body tissue dies): 2 people, 9.52%

What are the existing conditions these people have? *

Drug Dependence: 6 people, 28.57%
Stress And Anxiety: 2 people, 9.52%
Streptococcal Sepsis (whole body inflammation by streptococcal): 1 person, 4.76%
Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 1 person, 4.76%
Drug Abuse: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Subutex and have Peripheral ischaemia?

- Check whether Peripheral ischaemia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Subutex:

Subutex (8,763 reports)

Browse all side effects of Subutex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral ischaemia:

Peripheral ischaemia (574 drugs)

Browse all the conditions that are associated with Peripheral ischaemia:

Peripheral ischaemia (645 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on buprenorphine hydrochloride (the active ingredients of Subutex) and Subutex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.