Sudafed and Mydriasis - a phase IV clinical study of FDA data

Summary:

Mydriasis is reported as a side effect among people who take Sudafed (pseudoephedrine hydrochloride), especially for people who are female, 40-49 old, also take Claritin, and have Sneezing.

The phase IV clinical study analyzes which people have Mydriasis when taking Sudafed. It is created by eHealthMe based on reports of 11,196 people who have side effects when taking Sudafed from the FDA, and is updated regularly.

What is Sudafed?

Sudafed has active ingredients of pseudoephedrine hydrochloride. It is often used in nasal congestion. eHealthMe is studying from 12,944 Sudafed users. Check the latest studies of Sudafed.

What is Mydriasis?

Mydriasis (a dilation of the pupil) is found to be associated with 799 drugs and 1,151 conditions by eHealthMe. Check the latest studies of Mydriasis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

11,196 people reported to have side effects when taking Sudafed.
Among them, 25 people (0.22%) have Mydriasis.

Among these 25 people:

What is the gender of people who have Mydriasis when taking Sudafed? *

female: 73.91 %
male: 26.09 %

What is the age of people who have Mydriasis when taking Sudafed? *

What are other drugs people take besides Sudafed? *

What are other side effects people have besides Mydriasis? *

Vision Blurred: 4 people, 16.00%
Conjunctivitis (pink eye): 4 people, 16.00%
Glaucoma (increased fluid pressure in the eye with vision loss): 4 people, 16.00%
Cardiac Arrest: 4 people, 16.00%
Heart Rate Increased: 3 people, 12.00%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 3 people, 12.00%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 3 people, 12.00%
Depressed Level Of Consciousness: 3 people, 12.00%
Apnea (temporary absence or cessation of breathing): 3 people, 12.00%
Nausea (feeling of having an urge to vomit): 3 people, 12.00%

What are the existing conditions these people have? *

Sneezing: 4 people, 16.00%
Sinusitis (inflammation of sinus): 3 people, 12.00%
Sinus Disorder (disease of sinus): 1 person, 4.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 4.00%
Pain: 1 person, 4.00%
Muscle Spasms (muscle contraction): 1 person, 4.00%
Multiple Allergies (allergy to multiple agents): 1 person, 4.00%
Lacrimation Increased: 1 person, 4.00%
Insomnia (sleeplessness): 1 person, 4.00%
Eye Pruritus (eye itching): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Sudafed and have Mydriasis?

- Check whether Mydriasis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sudafed:

Sudafed (12,944 reports)

Mydriasis treatments and more:

Mydriasis (15,532 reports)

Browse all side effects of Sudafed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mydriasis:

Mydriasis (799 drugs)

Browse all the conditions that are associated with Mydriasis:

Mydriasis (1,151 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pseudoephedrine hydrochloride (the active ingredients of Sudafed) and Sudafed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.