Sulfamethoxazole and trimethoprim and Crohn's disease - a phase IV clinical study of FDA data

Summary:

Crohn's disease is reported as a side effect among people who take Sulfamethoxazole and trimethoprim (sulfamethoxazole; trimethoprim), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Diclofenac Sodium, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Crohn's disease when taking Sulfamethoxazole and trimethoprim. It is created by eHealthMe based on reports of 17,210 people who have side effects when taking Sulfamethoxazole and trimethoprim from the FDA, and is updated regularly.

What is Sulfamethoxazole and trimethoprim?

Sulfamethoxazole and trimethoprim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 17,645 Sulfamethoxazole and trimethoprim users. Check the latest studies of Sulfamethoxazole and trimethoprim.

What is Crohn's disease?

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract) is found to be associated with 1,352 drugs and 2,073 conditions by eHealthMe. Check the latest studies of Crohn's disease.

On Jul, 17, 2026

17,210 people reported to have side effects when taking Sulfamethoxazole and trimethoprim.
Among them, 63 people (0.37%) have Crohn's disease.

Could Sulfamethoxazole and trimethoprim cause Crohn's disease?

Among these 63 people:

How long have people been on Sulfamethoxazole and trimethoprim when they have Crohn's disease? *

What is the gender of people who have Crohn's disease when taking Sulfamethoxazole and trimethoprim? *

female: 82.46 %
male: 17.54 %

What is the age of people who have Crohn's disease when taking Sulfamethoxazole and trimethoprim? *

What are other drugs people take besides Sulfamethoxazole and trimethoprim? *

What are other side effects people have besides Crohn's disease? *

Pain: 31 people, 49.21%
Depression: 31 people, 49.21%
Irritable Bowel Syndrome: 30 people, 47.62%
High Blood Cholesterol: 30 people, 47.62%
Type 2 Diabetes: 28 people, 44.44%
Bone Erosion: 28 people, 44.44%
Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 28 people, 44.44%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 26 people, 41.27%
Exostosis (formation of new bone on the surface of a bone): 26 people, 41.27%
Breast Cancer Stage Iii: 26 people, 41.27%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 36 people, 57.14%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 29 people, 46.03%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 16 people, 25.40%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 15 people, 23.81%
Psoriasis (immune-mediated disease that affects the skin): 14 people, 22.22%
Fever: 12 people, 19.05%
Joint Pain: 7 people, 11.11%
Urticaria (rash of round, red welts on the skin that itch intensely): 7 people, 11.11%
Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 5 people, 7.94%
Stress And Anxiety: 5 people, 7.94%

* Approximation only. Some reports may have incomplete information.

Do you take Sulfamethoxazole and trimethoprim and have Crohn's disease?

- Check whether Crohn's disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sulfamethoxazole and trimethoprim:

Sulfamethoxazole and trimethoprim (17,645 reports)

Crohn's disease treatments and more:

Crohn's disease (390,234 reports)

How severe was Crohn's disease and when was it recovered:

Crohn's disease in Sulfamethoxazole and trimethoprim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Crohn's disease and drugs with ingredients of sulfamethoxazole; trimethoprim (479 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sulfamethoxazole and trimethoprim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Crohn's disease:

Crohn's disease (1,352 drugs)

Browse all the conditions that are associated with Crohn's disease:

Crohn's disease (2,073 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Sulfamethoxazole and trimethoprim) and Sulfamethoxazole and trimethoprim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.