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Topamax and Infusion site extravasation - a phase IV clinical study of FDA data

Summary:

Infusion site extravasation is reported as a side effect among people who take Topamax (topiramate), especially for people who are female, 40-49 old, also take Epinephrine, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Infusion site extravasation when taking Topamax. It is created by eHealthMe based on reports of 54,158 people who have side effects when taking Topamax from the FDA, and is updated regularly.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,955 Topamax users. Check the latest studies of Topamax.

What is Infusion site extravasation?

Infusion site extravasation (flow of (blood or lymph) from infusion site) is found to be associated with 649 drugs and 590 conditions by eHealthMe. Check the latest studies of Infusion site extravasation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

54,158 people reported to have side effects when taking Topamax.
Among them, 22 people (0.04%) have Infusion site extravasation.

Could Topamax cause Infusion site extravasation?

Among these 22 people:

What is the gender of people who have Infusion site extravasation when taking Topamax? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Infusion site extravasation when taking Topamax? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 33.33 %
  • 40-49: 66.67 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Topamax? *

  1. Acetaminophen: 16 people, 72.73%
  2. Epinephrine: 16 people, 72.73%
  3. Sodium Chloride: 12 people, 54.55%
  4. Vitamin D3: 10 people, 45.45%
  5. Lidocaine: 10 people, 45.45%
  6. Albuterol Sulfate: 8 people, 36.36%
  7. Zyrtec: 8 people, 36.36%
  8. Heparin: 7 people, 31.82%
  9. Aspirin: 7 people, 31.82%
  10. Gabapentin: 7 people, 31.82%

What are other side effects people have besides Infusion site extravasation? *

  1. Headache (pain in head): 11 people, 50.00%
  2. Sinusitis (inflammation of sinus): 9 people, 40.91%
  3. Infusion Site Swelling: 8 people, 36.36%
  4. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 8 people, 36.36%
  5. Fall: 6 people, 27.27%
  6. Infusion Site Erythema (reddening of the skin at infusion site): 6 people, 27.27%
  7. Pain: 6 people, 27.27%
  8. Head Injury: 6 people, 27.27%
  9. Fatigue (feeling of tiredness): 5 people, 22.73%
  10. Infusion Site Inflammation: 5 people, 22.73%

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 14 people, 63.64%
  2. Primary Immunodeficiency Syndrome: 2 people, 9.09%
  3. Myotonia (a state of hyperexcitability in muscle fibres in which a voluntary contraction): 2 people, 9.09%
  4. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 9.09%
  5. Combined Immunodeficiency: 2 people, 9.09%
  6. Stiff Person Syndrome: 1 person, 4.55%
  7. Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 1 person, 4.55%
  8. Myopathy (a muscular disease in which the muscle fibres do not function): 1 person, 4.55%
  9. Hereditary Angioedema (recurrent episodes of severe swelling): 1 person, 4.55%
  10. Bacteraemia (presence of bacteria in the blood): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Topamax and have Infusion site extravasation?

- Check whether Infusion site extravasation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topamax:

Infusion site extravasation treatments and more:

How severe was Infusion site extravasation and when was it recovered:

Expand to all the drugs that have ingredients of topiramate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Topamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Infusion site extravasation:

Browse all the conditions that are associated with Infusion site extravasation:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on topiramate (the active ingredients of Topamax) and Topamax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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