Trexall and Pneumonia - a phase IV clinical study of FDA data

Summary:

Pneumonia is reported as a side effect among people who take Trexall (methotrexate sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Enbrel, and have Ejection fraction decreased.

The phase IV clinical study analyzes which people have Pneumonia when taking Trexall. It is created by eHealthMe based on reports of 1,394 people who have side effects when taking Trexall from the FDA, and is updated regularly.

What is Trexall?

Trexall has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 1,439 Trexall users. Check the latest studies of Trexall.

What is Pneumonia?

Pneumonia is found to be associated with 3,351 drugs and 4,676 conditions by eHealthMe. Check the latest studies of Pneumonia.

On Jul, 13, 2026

1,394 people reported to have side effects when taking Trexall.
Among them, 29 people (2.08%) have Pneumonia.

Among these 29 people:

How long have people been on Trexall when they have Pneumonia? *

What is the gender of people who have Pneumonia when taking Trexall? *

female: 74.07 %
male: 25.93 %

What is the age of people who have Pneumonia when taking Trexall? *

What are other drugs people take besides Trexall? *

What are other side effects people have besides Pneumonia? *

Fever: 6 people, 20.69%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 5 people, 17.24%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 4 people, 13.79%
Thrombocytopenia (decrease of platelets in blood): 4 people, 13.79%
Memory Loss: 3 people, 10.34%
Itching: 3 people, 10.34%
Nausea (feeling of having an urge to vomit): 3 people, 10.34%
Septic Shock (shock due to blood infection): 3 people, 10.34%
Suicide Attempt: 3 people, 10.34%
Thrombosis (formation of a blood clot inside a blood vessel): 3 people, 10.34%

What are the existing conditions these people have? *

Ejection Fraction Decreased (systolic heart failure): 4 people, 13.79%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 6.90%
Multiple Myeloma (cancer of the plasma cells): 2 people, 6.90%
Diabetes: 2 people, 6.90%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 3.45%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 3.45%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Trexall and have Pneumonia?

- Check whether Pneumonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trexall:

Trexall (1,439 reports)

Pneumonia treatments and more:

Pneumonia (433,139 reports)

Browse all side effects of Trexall:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pneumonia:

Pneumonia (3,351 drugs)

Browse all the conditions that are associated with Pneumonia:

Pneumonia (4,676 conditions)

Related publications that referenced our studies

Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .
Henien M, Carey B, Hullah E, Sproat C, Patel V, "methotrexate-associated osteonecrosis of the jaw: A report of two cases", Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2017 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium (the active ingredients of Trexall) and Trexall (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.