Ultram and Hip joint replacement - a phase IV clinical study of FDA data

Summary:

Hip joint replacement is reported as a side effect among people who take Ultram (tramadol hydrochloride), especially for people who are female, 40-49 old, also take Fosamax, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Hip joint replacement when taking Ultram. It is created by eHealthMe based on reports of 26,802 people who have side effects when taking Ultram from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Hip joint replacement?

Hip joint replacement is found to be associated with 857 drugs and 1,063 conditions by eHealthMe. Check the latest studies of Hip joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

26,802 people reported to have side effects when taking Ultram.
Among them, 40 people (0.15%) have Hip joint replacement.

Could Ultram cause Hip joint replacement?

Among these 40 people:

What is the gender of people who have Hip joint replacement when taking Ultram? *

female: 75 %
male: 25 %

What is the age of people who have Hip joint replacement when taking Ultram? *

What are other drugs people take besides Ultram? *

Fosamax: 16 people, 40.00%
Humira: 12 people, 30.00%
Alendronate Sodium: 12 people, 30.00%
Acetaminophen: 11 people, 27.50%
Prednisone: 11 people, 27.50%
Methotrexate: 11 people, 27.50%
Naproxen: 11 people, 27.50%
Plaquenil: 11 people, 27.50%
Cetirizine Hydrochloride: 10 people, 25.00%
Remicade: 10 people, 25.00%

What are other side effects people have besides Hip joint replacement? *

High Blood Pressure: 18 people, 45.00%
Fatigue (feeling of tiredness): 18 people, 45.00%
Joint Pain: 18 people, 45.00%
Nausea (feeling of having an urge to vomit): 17 people, 42.50%
Pain In Extremity: 15 people, 37.50%
Fall: 15 people, 37.50%
Nausea And Vomiting: 14 people, 35.00%
Rashes (redness): 14 people, 35.00%
Stress And Anxiety: 13 people, 32.50%
Drug Ineffective: 13 people, 32.50%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 30.00%
Osteoporosis (bones weak and more likely to break): 4 people, 10.00%
Migraine (headache): 4 people, 10.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 7.50%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 7.50%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 7.50%
Hiv Infection: 3 people, 7.50%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 7.50%
Indigestion: 3 people, 7.50%
Nausea (feeling of having an urge to vomit): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and have Hip joint replacement?

- Check whether Hip joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ultram:

Ultram (28,425 reports)

Browse all side effects of Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hip joint replacement:

Hip joint replacement (857 drugs)

Browse all the conditions that are associated with Hip joint replacement:

Hip joint replacement (1,063 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Ultram) and Ultram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.