Vagifem and Tinnitus - a phase IV clinical study of FDA data

Summary:

Tinnitus is reported as a side effect among people who take Vagifem (estradiol), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Skin wrinkling.

The phase IV clinical study analyzes which people have Tinnitus when taking Vagifem. It is created by eHealthMe based on reports of 5,963 people who have side effects when taking Vagifem from the FDA, and is updated regularly.

What is Vagifem?

Vagifem has active ingredients of estradiol. It is often used in vulvovaginal dryness. eHealthMe is studying from 6,263 Vagifem users. Check the latest studies of Vagifem.

What is Tinnitus?

Tinnitus (a ringing in the ears) is found to be associated with 1,668 drugs and 3,060 conditions by eHealthMe. Check the latest studies of Tinnitus.

On Jul, 11, 2026

5,963 people reported to have side effects when taking Vagifem.
Among them, 27 people (0.45%) have Tinnitus.

Among these 27 people:

How long have people been on Vagifem when they have Tinnitus? *

What is the gender of people who have Tinnitus when taking Vagifem? *

female: 100 %
male: 0.0 %

What is the age of people who have Tinnitus when taking Vagifem? *

What are other drugs people take besides Vagifem? *

What are other side effects people have besides Tinnitus? *

Headache (pain in head): 7 people, 25.93%
Fatigue (feeling of tiredness): 6 people, 22.22%
Feeling Abnormal: 6 people, 22.22%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 6 people, 22.22%
Weakness: 5 people, 18.52%
Dizziness: 5 people, 18.52%
High Blood Pressure: 3 people, 11.11%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 3 people, 11.11%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 11.11%
Deafness Unilateral: 3 people, 11.11%

What are the existing conditions these people have? *

High Blood Pressure: 3 people, 11.11%
Multiple Myeloma (cancer of the plasma cells): 3 people, 11.11%
Skin Wrinkling (wrinkle on skin): 3 people, 11.11%
Headache (pain in head): 2 people, 7.41%
Neuropathy Peripheral (surface nerve damage): 2 people, 7.41%
Osteoporosis (bones weak and more likely to break): 2 people, 7.41%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 7.41%
Pain: 2 people, 7.41%
Migraine (headache): 2 people, 7.41%
Barrett's Oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Vagifem and have Tinnitus?

- Check whether Tinnitus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vagifem:

Vagifem (6,263 reports)

Tinnitus treatments and more:

Tinnitus (58,552 reports)

Browse all side effects of Vagifem:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tinnitus:

Tinnitus (1,668 drugs)

Browse all the conditions that are associated with Tinnitus:

Tinnitus (3,060 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Vagifem) and Vagifem (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.