Valerian and Restlessness aggravated - a phase IV clinical study of FDA data

Summary:

Restlessness aggravated is reported as a side effect among people who take Valerian (valerian), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Zopiclone, and have Nasopharyngitis.

The phase IV clinical study analyzes which people have Restlessness aggravated when taking Valerian. It is created by eHealthMe based on reports of 1,083 people who have side effects when taking Valerian from the FDA, and is updated regularly.

What is Valerian?

Valerian has active ingredients of valerian. It is often used in insomnia. eHealthMe is studying from 1,271 Valerian users. Check the latest studies of Valerian.

What is Restlessness aggravated?

Restlessness aggravated (not able to rest) is found to be associated with 1,516 drugs and 562 conditions by eHealthMe. Check the latest studies of Restlessness aggravated.

On Jul, 09, 2026

1,083 people reported to have side effects when taking Valerian.
Among them, 45 people (4.16%) have Restlessness aggravated.

Could Valerian cause Restlessness aggravated?

Among these 45 people:

How long have people been on Valerian when they have Restlessness aggravated? *

What is the gender of people who have Restlessness aggravated when taking Valerian? *

female: 25 %
male: 75 %

What is the age of people who have Restlessness aggravated when taking Valerian? *

What are other drugs people take besides Valerian? *

Zopiclone: 10 people, 22.22%
Folic Acid: 9 people, 20.00%
Acetaminophen: 9 people, 20.00%
Valproic Acid: 8 people, 17.78%
Metoclopramide Hydrochloride: 8 people, 17.78%
Phenytoin: 8 people, 17.78%
Carbamazepine: 8 people, 17.78%
Valproate Sodium: 8 people, 17.78%
Ranitidine: 8 people, 17.78%
Allopurinol: 7 people, 15.56%

What are other side effects people have besides Restlessness aggravated? *

Fatigue (feeling of tiredness): 27 people, 60.00%
Nausea (feeling of having an urge to vomit): 25 people, 55.56%
Itching: 17 people, 37.78%
Aspartate Aminotransferase Increased: 17 people, 37.78%
Swallowing Difficulty: 17 people, 37.78%
Alanine Aminotransferase Increased: 17 people, 37.78%
Gamma-Glutamyltransferase Increased: 16 people, 35.56%
Swelling Face: 16 people, 35.56%
Nasopharyngitis (inflammation of the nasopharynx): 16 people, 35.56%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 16 people, 35.56%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 16 people, 35.56%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 16 people, 35.56%
Fatigue (feeling of tiredness): 16 people, 35.56%
Nasopharyngitis (inflammation of the nasopharynx): 16 people, 35.56%
Abdominal Distension: 8 people, 17.78%
High Blood Pressure: 7 people, 15.56%
Birth Control: 4 people, 8.89%
Urinary Tract Infection: 4 people, 8.89%
Prostatitis (inflammation of the prostate gland): 4 people, 8.89%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

Do you take Valerian and have Restlessness aggravated?

- Check whether Restlessness aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valerian:

Valerian (1,271 reports)

Browse all side effects of Valerian:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Restlessness aggravated:

Restlessness aggravated (1,516 drugs)

Browse all the conditions that are associated with Restlessness aggravated:

Restlessness aggravated (562 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valerian (the active ingredients of Valerian) and Valerian (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.