Vioxx and Histoplasmosis - a phase IV clinical study of FDA data

Summary:

Histoplasmosis is reported as a side effect among people who take Vioxx (rofecoxib), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Remicade, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Histoplasmosis when taking Vioxx. It is created by eHealthMe based on reports of 110,097 people who have side effects when taking Vioxx from the FDA, and is updated regularly.

What is Vioxx?

Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 110,130 Vioxx users. Check the latest studies of Vioxx.

What is Histoplasmosis?

Histoplasmosis (infection caused by breathing in spores of a fungus) is found to be associated with 256 drugs and 359 conditions by eHealthMe. Check the latest studies of Histoplasmosis.

On Jul, 11, 2026

110,097 people reported to have side effects when taking Vioxx.
Among them, 18 people (0.02%) have Histoplasmosis.

Among these 18 people:

How long have people been on Vioxx when they have Histoplasmosis? *

What is the gender of people who have Histoplasmosis when taking Vioxx? *

female: 72.22 %
male: 27.78 %

What is the age of people who have Histoplasmosis when taking Vioxx? *

What are other drugs people take besides Vioxx? *

What are other side effects people have besides Histoplasmosis? *

Weakness: 7 people, 38.89%
Cerebral Atrophy (decrement in size of brain): 6 people, 33.33%
Dyspnea (difficult or laboured breathing): 6 people, 33.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 6 people, 33.33%
Pneumonia: 6 people, 33.33%
Hyperkeratosis (thickening of the outer layer of the skin): 5 people, 27.78%
Hypertrophic Cardiomyopathy (a condition in which the heart muscle becomes abnormally thick): 5 people, 27.78%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 5 people, 27.78%
Emotional Distress: 5 people, 27.78%
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 5 people, 27.78%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 33.33%
Neoplasm Malignant (cancer tumour): 5 people, 27.78%
Metastases To Spine (cancer spreads to spine): 5 people, 27.78%
Calcium Deficiency (lack of calcium): 5 people, 27.78%
Lung Neoplasm (tumour of lung): 4 people, 22.22%
Metastases To Bone (cancer spreads to bone): 2 people, 11.11%
Breast Cancer: 2 people, 11.11%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 1 person, 5.56%
Pulmonary Mass: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Vioxx and have Histoplasmosis?

- Check whether Histoplasmosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vioxx:

Vioxx (110,130 reports)

Histoplasmosis treatments and more:

Histoplasmosis (2,534 reports)

Browse all side effects of Vioxx:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Histoplasmosis:

Histoplasmosis (257 drugs)

Browse all the conditions that are associated with Histoplasmosis:

Histoplasmosis (359 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rofecoxib (the active ingredients of Vioxx) and Vioxx (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.