Norflex and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norflex (orphenadrine citrate) and Flonase (fluticasone propionate). Common drug interactions include carotid bruit among females and acute psychosis among males.

The phase IV clinical study analyzes what interactions people have when they take Norflex and Flonase. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Norflex?

Norflex has active ingredients of orphenadrine citrate. It is often used in muscle spasms. eHealthMe is studying from 1,951 Norflex users. Check the latest studies of Norflex.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

On Jul, 11, 2026

46 people who take Norflex and Flonase together, and have interactions are studied.

What are the common drug interactions of Norflex and Flonase, by gender? *:

female:

Carotid bruit (sound heard over the carotid artery area during auscultation)
Cellulitis (infection under the skin)
Cervical cyst (mucus-filled cyst on the surface of the cervix)
Chest discomfort
Chest pain
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Conjunctival haemorrhage (bleeding underneath the conjunctiva)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite

male:

Acute psychosis (period of mentally unstable behaviour)
Agitation (state of anxiety or nervous excitement)
Polysubstance abuse
Rash
Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Blood pressure increased
Emotional distress
Hallucination (an experience involving the perception of something not present)
Muscle contractions involuntary (uncontrolled muscle contraction)

What are the common drug interactions of Norflex and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug administration error

20-29:

n/a

30-39:

Gallbladder injury

40-49:

Hallucination, visual (seeing things that aren't there)
Homicidal ideation (thoughts about human killing another human)
Hyperkeratosis (thickening of the outer layer of the skin)
Interstitial lung disease
Irritability
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Mitral valve stenosis (narrowing of mitral valve)
Muscle contractions involuntary (uncontrolled muscle contraction)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pericardial effusion (fluid around the heart)

50-59:

Intestinal obstruction
Abdominal adhesions (inflammation of abdomen)
Abdominal distension
Acne (skin problems that cause pimples)
Chronic kidney disease
Constipation
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Hypersensitivity
Intestinal mass

60+:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Blood pressure increased
Breast cancer stage i
Cellulitis (infection under the skin)
Cholecystitis (infection of gallbladder)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug ineffective

What are the existing conditions these people have? *

Pain: 11 people, 23.91%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 17.39%
Depression: 6 people, 13.04%
Multiple Allergies (allergy to multiple agents): 5 people, 10.87%
Headache (pain in head): 5 people, 10.87%
Sleep Disorder: 4 people, 8.70%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 8.70%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 8.70%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.70%
Inflammation: 4 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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