Vitamin b12 and Inappropriate affect - a phase IV clinical study of FDA data

Summary:

Inappropriate affect is reported as a side effect among people who take Vitamin b12 (cobalamin), especially for people who are male, 20-29 old, also take Magnesium, and have Schizophrenia.

The phase IV clinical study analyzes which people have Inappropriate affect when taking Vitamin b12. It is created by eHealthMe based on reports of 119,611 people who have side effects when taking Vitamin b12 from the FDA, and is updated regularly.

What is Vitamin b12?

Vitamin b12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,681 Vitamin b12 users. Check the latest studies of Vitamin b12.

What is Inappropriate affect?

Inappropriate affect is found to be associated with 255 drugs and 385 conditions by eHealthMe. Check the latest studies of Inappropriate affect.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

119,611 people reported to have side effects when taking Vitamin b12.
Among them, 18 people (0.02%) have Inappropriate affect.

Could Vitamin b12 cause Inappropriate affect?

Among these 18 people:

What is the gender of people who have Inappropriate affect when taking Vitamin b12? *

female: 44.44 %
male: 55.56 %

What is the age of people who have Inappropriate affect when taking Vitamin b12? *

What are other drugs people take besides Vitamin b12? *

What are other side effects people have besides Inappropriate affect? *

Weakness: 7 people, 38.89%
Mental Impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 6 people, 33.33%
Insomnia (sleeplessness): 6 people, 33.33%
Balance Disorder: 6 people, 33.33%
Mood Swings (an extreme or rapid change in mood): 6 people, 33.33%
Drowsiness: 5 people, 27.78%
Weight Increased: 5 people, 27.78%
Psychomotor Hyperactivity (feelings of extreme restlessness): 5 people, 27.78%
Apathy: 5 people, 27.78%
Hallucination, Auditory (perceiving sounds without auditory stimulus): 5 people, 27.78%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 27.78%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 22.22%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 11.11%
Parkinson's Disease: 1 person, 5.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.56%
Iron Deficiency: 1 person, 5.56%
Intracranial Pressure Increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid): 1 person, 5.56%
Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 1 person, 5.56%
Gait Disturbance: 1 person, 5.56%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin b12 and have Inappropriate affect?

- Check whether Inappropriate affect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin b12:

Vitamin b12 (121,681 reports)

Browse all side effects of Vitamin b12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Inappropriate affect:

Inappropriate affect (255 drugs)

Browse all the conditions that are associated with Inappropriate affect:

Inappropriate affect (385 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cobalamin (the active ingredients of Vitamin b12) and Vitamin b12 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.