Vitamin c and Extremity necrosis - a phase IV clinical study of FDA data

Summary:

Extremity necrosis is reported as a side effect among people who take Vitamin c (l-ascorbic acid), especially for people who are male, 60+ old, have been taking the drug for 10+ years also take Argatroban, and have Atrial fibrillation/flutter.

The phase IV clinical study analyzes which people have Extremity necrosis when taking Vitamin c. It is created by eHealthMe based on reports of 89,802 people who have side effects when taking Vitamin c from the FDA, and is updated regularly.

What is Vitamin c?

Vitamin c has active ingredients of l-ascorbic acid. It is often used in immune response. eHealthMe is studying from 92,472 Vitamin c users. Check the latest studies of Vitamin c.

What is Extremity necrosis?

Extremity necrosis (death of body tissue of arms and legs) is found to be associated with 296 drugs and 412 conditions by eHealthMe. Check the latest studies of Extremity necrosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

89,802 people reported to have side effects when taking Vitamin c.
Among them, 11 people (0.01%) have Extremity necrosis.

Could Vitamin c cause Extremity necrosis?

Among these 11 people:

How long have people been on Vitamin c when they have Extremity necrosis? *

What is the gender of people who have Extremity necrosis when taking Vitamin c? *

female: 27.27 %
male: 72.73 %

What is the age of people who have Extremity necrosis when taking Vitamin c? *

What are other drugs people take besides Vitamin c? *

Methylprednisolone: 4 people, 36.36%
Ceftriaxone: 4 people, 36.36%
Methotrexate: 4 people, 36.36%
Epinephrine: 4 people, 36.36%
Thiamine: 4 people, 36.36%
Argatroban: 4 people, 36.36%
Celebrex: 2 people, 18.18%
Cyclocort: 2 people, 18.18%
Enbrel: 2 people, 18.18%
Norepinephrine Bitartrate: 2 people, 18.18%

What are other side effects people have besides Extremity necrosis? *

Localised Infection (infection at the single location): 6 people, 54.55%
Nausea (feeling of having an urge to vomit): 4 people, 36.36%
Drug Ineffective: 4 people, 36.36%
Gangrene (body tissue dies): 3 people, 27.27%
Dry Gangrene (diminished blood supply due to vascular problems): 3 people, 27.27%
Constipation: 2 people, 18.18%
Feeling Hot: 2 people, 18.18%
Fall: 2 people, 18.18%
Ecg Signs Of Myocardial Ischaemia: 2 people, 18.18%
Dysstasia (difficulty in standing): 2 people, 18.18%

What are the existing conditions these people have? *

Hypotension (abnormally low blood pressure): 4 people, 36.36%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 36.36%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 3 people, 27.27%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 27.27%
Skin Haemorrhage (bleeding into skin): 2 people, 18.18%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 18.18%
Cellulitis (infection under the skin): 2 people, 18.18%
Gout (uric acid crystals building up in the body): 2 people, 18.18%
High Blood Cholesterol: 2 people, 18.18%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin c and have Extremity necrosis?

- Check whether Extremity necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin c:

Vitamin c (92,472 reports)

Browse all side effects of Vitamin c:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Extremity necrosis:

Extremity necrosis (296 drugs)

Browse all the conditions that are associated with Extremity necrosis:

Extremity necrosis (412 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on l-ascorbic acid (the active ingredients of Vitamin c) and Vitamin c (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.