Wellbutrin and Paraplegia - a phase IV clinical study of FDA data

Summary:

Paraplegia is reported as a side effect among people who take Wellbutrin (bupropion hydrochloride), especially for people who are female, 60+ old, also take Adderall, and have Muscle spasms.

The phase IV clinical study analyzes which people have Paraplegia when taking Wellbutrin. It is created by eHealthMe based on reports of 101,581 people who have side effects when taking Wellbutrin from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,107 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Paraplegia?

Paraplegia (paralysis of the legs and lower body) is found to be associated with 440 drugs and 535 conditions by eHealthMe. Check the latest studies of Paraplegia.

On Jul, 06, 2026

101,581 people reported to have side effects when taking Wellbutrin.
Among them, 12 people (0.01%) have Paraplegia.

Among these 12 people:

What is the gender of people who have Paraplegia when taking Wellbutrin? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Paraplegia when taking Wellbutrin? *

What are other drugs people take besides Wellbutrin? *

Adderall: 4 people, 33.33%
Vitamin D3: 3 people, 25.00%
Hydrocodone Bitartrate And Acetaminophen: 3 people, 25.00%
Zoloft: 2 people, 16.67%
Dilaudid: 2 people, 16.67%
Lyrica: 2 people, 16.67%
Levaquin: 2 people, 16.67%
Nuvigil: 2 people, 16.67%
Zanaflex: 2 people, 16.67%
Oxycodone: 2 people, 16.67%

What are other side effects people have besides Paraplegia? *

Pain: 4 people, 33.33%
Feeling Abnormal: 3 people, 25.00%
Drug Ineffective: 3 people, 25.00%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 16.67%
Fall: 2 people, 16.67%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 16.67%
Upper-Airway Cough Syndrome: 2 people, 16.67%
Intervertebral Disc Degeneration (spinal disc degeneration): 2 people, 16.67%
Irritable Bowel Syndrome: 2 people, 16.67%
Dysstasia (difficulty in standing): 2 people, 16.67%

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 4 people, 33.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 25.00%
Polymyalgia Rheumatica (pain in many muscles): 2 people, 16.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 16.67%
Drowsiness: 2 people, 16.67%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 16.67%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 8.33%
Pain: 1 person, 8.33%
Neuralgia (pain in one or more nerves): 1 person, 8.33%
Muscle Aches (muscle pain): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and have Paraplegia?

- Check whether Paraplegia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin:

Wellbutrin (117,107 reports)

Paraplegia treatments and more:

Paraplegia (3,983 reports)

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Paraplegia:

Paraplegia (440 drugs)

Browse all the conditions that are associated with Paraplegia:

Paraplegia (535 conditions)

Related publications that referenced our studies

Lee, Y. J., & Park, K. , "Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension", Drug safety-case reports, 2018 Jan .
Lee, Y. J., & Park, K. , "Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension", Drug safety-case reports, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin) and Wellbutrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.