Xanax and Muscle rupture - a phase IV clinical study of FDA data

Summary:

Muscle rupture is reported as a side effect among people who take Xanax (alprazolam), especially for people who are female, 50-59 old, also take Humira, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Muscle rupture when taking Xanax. It is created by eHealthMe based on reports of 126,784 people who have side effects when taking Xanax from the FDA, and is updated regularly.

What is Xanax?

Xanax has active ingredients of alprazolam. It is often used in stress and anxiety. eHealthMe is studying from 135,347 Xanax users. Check the latest studies of Xanax.

What is Muscle rupture?

Muscle rupture (tear in muscle) is found to be associated with 395 drugs and 509 conditions by eHealthMe. Check the latest studies of Muscle rupture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

126,784 people reported to have side effects when taking Xanax.
Among them, 32 people (0.03%) have Muscle rupture.

Among these 32 people:

What is the gender of people who have Muscle rupture when taking Xanax? *

female: 53.12 %
male: 46.88 %

What is the age of people who have Muscle rupture when taking Xanax? *

What are other drugs people take besides Xanax? *

What are other side effects people have besides Muscle rupture? *

Pain In Extremity: 13 people, 40.62%
Fall: 12 people, 37.50%
Pain: 12 people, 37.50%
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 9 people, 28.12%
Tendon Rupture (tear of tendon): 9 people, 28.12%
Fatigue (feeling of tiredness): 9 people, 28.12%
Back Pain: 8 people, 25.00%
Muscle Spasms (muscle contraction): 6 people, 18.75%
Joint Pain: 6 people, 18.75%
Hypoaesthesia (reduced sense of touch or sensation): 6 people, 18.75%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 28.12%
High Blood Cholesterol: 9 people, 28.12%
Depression: 7 people, 21.88%
Pain: 7 people, 21.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 21.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 15.62%
Sleep Disorder: 4 people, 12.50%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 12.50%
High Blood Pressure: 3 people, 9.38%
Neuropathy Peripheral (surface nerve damage): 3 people, 9.38%

* Approximation only. Some reports may have incomplete information.

Do you take Xanax and have Muscle rupture?

- Check whether Muscle rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xanax:

Xanax (135,347 reports)

Muscle rupture treatments and more:

Muscle rupture (4,655 reports)

Browse all side effects of Xanax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rupture:

Muscle rupture (395 drugs)

Browse all the conditions that are associated with Muscle rupture:

Muscle rupture (509 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on alprazolam (the active ingredients of Xanax) and Xanax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.