Xiaflex and Weakness - a phase IV clinical study of FDA data

Summary:

Weakness is reported as a side effect among people who take Xiaflex (collagenase clostridium histolyticum), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Curvature of the penis.

The phase IV clinical study analyzes which people have Weakness when taking Xiaflex. It is created by eHealthMe based on reports of 5,175 people who have side effects when taking Xiaflex from the FDA, and is updated regularly.

What is Xiaflex?

Xiaflex has active ingredients of collagenase clostridium histolyticum. eHealthMe is studying from 5,177 Xiaflex users. Check the latest studies of Xiaflex.

What is Weakness?

Weakness is found to be associated with 3,639 drugs and 6,565 conditions by eHealthMe. Check the latest studies of Weakness.

On Nov, 11, 2025

5,175 people reported to have side effects when taking Xiaflex.
Among them, 44 people (0.85%) have Weakness.

Among these 44 people:

How long have people been on Xiaflex when they have Weakness? *

What is the gender of people who have Weakness when taking Xiaflex? *

female: 15.38 %
male: 84.62 %

What is the age of people who have Weakness when taking Xiaflex? *

What are other drugs people take besides Xiaflex? *

What are other side effects people have besides Weakness? *

Pain In Extremity: 14 people, 31.82%
Fever: 11 people, 25.00%
Fatigue (feeling of tiredness): 10 people, 22.73%
Dizziness: 10 people, 22.73%
Head Injury: 9 people, 20.45%
Chills (felling of cold): 8 people, 18.18%
Staphylococcal Infection (an infection with staphylococcus bacteria): 8 people, 18.18%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 8 people, 18.18%
Drug Ineffective: 7 people, 15.91%
Nausea (feeling of having an urge to vomit): 7 people, 15.91%

What are the existing conditions these people have? *

Curvature Of The Penis: 19 people, 43.18%
Dupuytren's Contracture (thickening of the fibrous tissue layer underneath the skin of the palm and fingers): 15 people, 34.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 15.91%
Stress And Anxiety: 5 people, 11.36%
Diabetes: 5 people, 11.36%
Renal Cell Carcinoma (a kidney cancer): 5 people, 11.36%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 5 people, 11.36%
High Blood Pressure: 5 people, 11.36%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 9.09%
Depression: 4 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Xiaflex and have Weakness?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xiaflex:

Xiaflex (5,177 reports)

Weakness treatments and more:

Weakness (586,868 reports)

How severe was Weakness and when was it recovered:

Weakness in Xiaflex

Expand to all the drugs that have ingredients of collagenase clostridium histolyticum:

Weakness and drugs with ingredients of collagenase clostridium histolyticum (38 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xiaflex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weakness:

Weakness (3,639 drugs)

Browse all the conditions that are associated with Weakness:

Weakness (6,565 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on collagenase clostridium histolyticum (the active ingredients of Xiaflex) and Xiaflex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.