Xywav and Initial insomnia - a phase IV clinical study of FDA data

Summary:

Initial insomnia is reported as a side effect among people who take Xywav (calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate), especially for people who are female, 30-39 old, also take Aripiprazole, and have Drowsiness.

The phase IV clinical study analyzes which people have Initial insomnia when taking Xywav. It is created by eHealthMe based on reports of 7,111 people who have side effects when taking Xywav from the FDA, and is updated regularly.

What is Xywav?

Xywav has active ingredients of calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate. eHealthMe is studying from 7,134 Xywav users. Check the latest studies of Xywav.

What is Initial insomnia?

Initial insomnia (feeling of inadequate or poor-quality sleep) is found to be associated with 717 drugs and 689 conditions by eHealthMe. Check the latest studies of Initial insomnia.

On Jul, 21, 2026

7,111 people reported to have side effects when taking Xywav.
Among them, 15 people (0.21%) have Initial insomnia.

Among these 15 people:

What is the gender of people who have Initial insomnia when taking Xywav? *

female: 80 %
male: 20 %

What is the age of people who have Initial insomnia when taking Xywav? *

What are other drugs people take besides Xywav? *

What are other side effects people have besides Initial insomnia? *

Nausea (feeling of having an urge to vomit): 10 people, 66.67%
Dizziness: 9 people, 60.00%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 8 people, 53.33%
Weight Decreased: 6 people, 40.00%
Feeling Abnormal: 6 people, 40.00%
Fatigue (feeling of tiredness): 6 people, 40.00%
Eye Irritation: 5 people, 33.33%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 33.33%
Lacrimation Increased: 5 people, 33.33%
Tinnitus (a ringing in the ears): 5 people, 33.33%

What are the existing conditions these people have? *

Drowsiness: 13 people, 86.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 46.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 33.33%
Nausea (feeling of having an urge to vomit): 3 people, 20.00%
Abdominal Discomfort: 3 people, 20.00%
Hypersensitivity: 2 people, 13.33%
Weight Decreased: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Xywav and have Initial insomnia?

- Check whether Initial insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Xywav:

Xywav (7,134 reports)

Initial insomnia treatments and more:

Initial insomnia (12,139 reports)

How severe was Initial insomnia and when was it recovered:

Initial insomnia in Xywav

Expand to all the drugs that have ingredients of calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate:

Initial insomnia and drugs with ingredients of calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Xywav:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Initial insomnia:

Initial insomnia (717 drugs)

Browse all the conditions that are associated with Initial insomnia:

Initial insomnia (689 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on calcium oxybate; magnesium oxybate; potassium oxybate; sodium oxybate (the active ingredients of Xywav) and Xywav (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.