Zantac 75 and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Zantac 75 (ranitidine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Prevacid, and have Cardiac disorder.

The phase IV clinical study analyzes which people have Malaise when taking Zantac 75. It is created by eHealthMe based on reports of 3,615 people who have side effects when taking Zantac 75 from the FDA, and is updated regularly.

What is Zantac 75?

Zantac 75 has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 3,796 Zantac 75 users. Check the latest studies of Zantac 75.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,492 drugs and 5,126 conditions by eHealthMe. Check the latest studies of Malaise.

On Aug, 06, 2026

3,615 people reported to have side effects when taking Zantac 75.
Among them, 54 people (1.49%) have Malaise.

Among these 54 people:

How long have people been on Zantac 75 when they have Malaise? *

What is the gender of people who have Malaise when taking Zantac 75? *

female: 78.95 %
male: 21.05 %

What is the age of people who have Malaise when taking Zantac 75? *

What are other drugs people take besides Zantac 75? *

What are other side effects people have besides Malaise? *

Diarrhea: 10 people, 18.52%
Drug Ineffective: 6 people, 11.11%
Headache (pain in head): 6 people, 11.11%
Nausea (feeling of having an urge to vomit): 6 people, 11.11%
Fatigue (feeling of tiredness): 6 people, 11.11%
Depression: 5 people, 9.26%
Abdominal Pain Upper: 4 people, 7.41%
Multi-Organ Disorder (multiple organ disease): 4 people, 7.41%
Nausea And Vomiting: 4 people, 7.41%
Rashes (redness): 4 people, 7.41%

What are the existing conditions these people have? *

Pain: 6 people, 11.11%
Cardiac Disorder: 6 people, 11.11%
High Blood Pressure: 4 people, 7.41%
Cough: 3 people, 5.56%
Dyspnea (difficult or laboured breathing): 3 people, 5.56%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.56%
Wheezing (a high-pitched whistling sound made while you breath): 3 people, 5.56%
Acne (skin problems that cause pimples): 3 people, 5.56%
Stress And Anxiety: 3 people, 5.56%
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose): 3 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Zantac 75 and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zantac 75:

Zantac 75 (3,796 reports)

Malaise treatments and more:

Malaise (529,933 reports)

Browse all side effects of Zantac 75:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,492 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,126 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ranitidine hydrochloride (the active ingredients of Zantac 75) and Zantac 75 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.