Zepbound and Weight increased - a phase IV clinical study of FDA data

Summary:

Weight increased is reported as a side effect among people who take Zepbound (tirzepatide), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Cymbalta, and have Weight loss.

The phase IV clinical study analyzes which people have Weight increased when taking Zepbound. It is created by eHealthMe based on reports of 1,514 people who have side effects when taking Zepbound from the FDA, and is updated regularly.

What is Zepbound?

Zepbound has active ingredients of tirzepatide. eHealthMe is studying from 1,524 Zepbound users. Check the latest studies of Zepbound.

What is Weight increased?

Weight increased is found to be associated with 2,906 drugs and 3,887 conditions by eHealthMe. Check the latest studies of Weight increased.

On Aug, 24, 2025

1,514 people reported to have side effects when taking Zepbound.
Among them, 22 people (1.45%) have Weight increased.

Among these 22 people:

How long have people been on Zepbound when they have Weight increased? *

What is the gender of people who have Weight increased when taking Zepbound? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Weight increased when taking Zepbound? *

What are other drugs people take besides Zepbound? *

What are other side effects people have besides Weight increased? *

Injection Site Haemorrhage (bleeding from injection site): 6 people, 27.27%
Nausea (feeling of having an urge to vomit): 4 people, 18.18%
Drug Ineffective: 4 people, 18.18%
Injection Site Pain: 4 people, 18.18%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 4 people, 18.18%
Food Craving: 2 people, 9.09%
Injection Site Bruising: 2 people, 9.09%
Nasopharyngitis (inflammation of the nasopharynx): 1 person, 4.55%
Headache (pain in head): 1 person, 4.55%
Back Pain: 1 person, 4.55%

What are the existing conditions these people have? *

Weight Loss: 13 people, 59.09%
Obstructive Sleep Apnea Syndrome (a sleep disorder that involves cessation or significant decrease in airflow in the presence of breathing effort): 1 person, 4.55%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 4.55%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Zepbound and have Weight increased?

- Check whether Weight increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zepbound:

Zepbound (1,524 reports)

Weight increased treatments and more:

Weight increased (279,360 reports)

How severe was Weight increased and when was it recovered:

Weight increased in Zepbound

Browse all side effects of Zepbound:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight increased:

Weight increased (2,906 drugs)

Browse all the conditions that are associated with Weight increased:

Weight increased (3,887 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tirzepatide (the active ingredients of Zepbound) and Zepbound (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.