Zestril and Impaired work ability - a phase IV clinical study of FDA data

Summary:

Impaired work ability is reported as a side effect among people who take Zestril (lisinopril), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Prinivil, and have Neuropathy peripheral.

The phase IV clinical study analyzes which people have Impaired work ability when taking Zestril. It is created by eHealthMe based on reports of 21,786 people who have side effects when taking Zestril from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Impaired work ability?

Impaired work ability is found to be associated with 1,011 drugs and 1,137 conditions by eHealthMe. Check the latest studies of Impaired work ability.



On Jul, 19, 2026

21,786 people reported to have side effects when taking Zestril.
Among them, 34 people (0.16%) have Impaired work ability.

Could Zestril cause Impaired work ability?

Among these 34 people:

How long have people been on Zestril when they have Impaired work ability? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 50 %
  • 10+ years: 0.0 %

What is the gender of people who have Impaired work ability when taking Zestril? *

  • female: 47.06 %
  • male: 52.94 %

What is the age of people who have Impaired work ability when taking Zestril? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 9.09 %
  • 40-49: 24.24 %
  • 50-59: 18.18 %
  • 60+: 48.48 %

What are other drugs people take besides Zestril? *

  1. Prinivil: 15 people, 44.12%
  2. Pravachol: 12 people, 35.29%
  3. Lyrica: 12 people, 35.29%
  4. Lasix: 10 people, 29.41%
  5. Flexeril: 9 people, 26.47%
  6. Coreg: 8 people, 23.53%
  7. Lodine: 7 people, 20.59%
  8. Lopid: 7 people, 20.59%
  9. Nasonex: 7 people, 20.59%
  10. Glucophage Xr: 7 people, 20.59%

What are other side effects people have besides Impaired work ability? *

  1. Pain: 9 people, 26.47%
  2. Malaise (a feeling of general discomfort or uneasiness): 8 people, 23.53%
  3. Dizziness: 8 people, 23.53%
  4. Peripheral Swelling: 7 people, 20.59%
  5. Cough: 6 people, 17.65%
  6. Diarrhea: 5 people, 14.71%
  7. Pericardial Effusion (fluid around the heart): 5 people, 14.71%
  8. Cardiac Failure: 5 people, 14.71%
  9. Cardiac Failure Congestive: 5 people, 14.71%
  10. Fatigue (feeling of tiredness): 5 people, 14.71%

What are the existing conditions these people have? *

  1. Muscle Spasms (muscle contraction): 9 people, 26.47%
  2. Neuropathy Peripheral (surface nerve damage): 9 people, 26.47%
  3. Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 7 people, 20.59%
  4. Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 14.71%
  5. Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 11.76%
  6. Hypotension (abnormally low blood pressure): 4 people, 11.76%
  7. Immunodeficiency Disorders: 4 people, 11.76%
  8. Dry Skin: 4 people, 11.76%
  9. Pulmonary Embolism (blockage of the main artery of the lung): 4 people, 11.76%
  10. Cardiac Disorder: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

Do you take Zestril and have Impaired work ability?

- Check whether Impaired work ability is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zestril:

Impaired work ability treatments and more:

How severe was Impaired work ability and when was it recovered:

Expand to all the drugs that have ingredients of lisinopril:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Impaired work ability:

Browse all the conditions that are associated with Impaired work ability:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on lisinopril (the active ingredients of Zestril) and Zestril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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