Zide and Eyelid margin crusting - a phase IV clinical study of FDA data

Summary:

Eyelid margin crusting is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are female, 60+ old, also take Dupixent, and have Dermatitis atopic.

The phase IV clinical study analyzes which people have Eyelid margin crusting when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Eyelid margin crusting?

Eyelid margin crusting (crusting at the lid margins, generally worse on waking) is found to be associated with 196 drugs and 279 conditions by eHealthMe. Check the latest studies of Eyelid margin crusting.

On Jul, 09, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 36 people (0.02%) have Eyelid margin crusting.

Could Zide cause Eyelid margin crusting?

Among these 36 people:

What is the gender of people who have Eyelid margin crusting when taking Zide? *

female: 68.57 %
male: 31.43 %

What is the age of people who have Eyelid margin crusting when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Eyelid margin crusting? *

Eye Swelling: 12 people, 33.33%
Ocular Hyperaemia (an abnormally large amount of blood in eye): 11 people, 30.56%
Eye Pruritus (eye itching): 11 people, 30.56%
Rashes (redness): 10 people, 27.78%
Dyspnea (difficult or laboured breathing): 7 people, 19.44%
Lacrimation Increased: 6 people, 16.67%
Dry Eyes (lack of adequate tears): 6 people, 16.67%
Mouth Ulcers: 6 people, 16.67%
Eye Pain: 5 people, 13.89%
Itching: 5 people, 13.89%

What are the existing conditions these people have? *

Asthma: 6 people, 16.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 6 people, 16.67%
Malaria (a parasitic disease due to mosquito bite): 6 people, 16.67%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 6 people, 16.67%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 8.33%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 2 people, 5.56%
Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 5.56%
Dry Eyes (lack of adequate tears): 1 person, 2.78%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 2.78%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Eyelid margin crusting?

- Check whether Eyelid margin crusting is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,246 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Eyelid margin crusting:

Eyelid margin crusting (196 drugs)

Browse all the conditions that are associated with Eyelid margin crusting:

Eyelid margin crusting (279 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.