Zide and Hepatocellular carcinoma - a phase IV clinical study of FDA data

Summary:

Hepatocellular carcinoma is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Nexavar, and have Hepatitis c.

The phase IV clinical study analyzes which people have Hepatocellular carcinoma when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,247 Zide users. Check the latest studies of Zide.

What is Hepatocellular carcinoma?

Hepatocellular carcinoma (liver cancer) is found to be associated with 306 drugs and 733 conditions by eHealthMe. Check the latest studies of Hepatocellular carcinoma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 31 people (0.02%) have Hepatocellular carcinoma.

Could Zide cause Hepatocellular carcinoma?

Among these 31 people:

How long have people been on Zide when they have Hepatocellular carcinoma? *

What is the gender of people who have Hepatocellular carcinoma when taking Zide? *

female: 38.71 %
male: 61.29 %

What is the age of people who have Hepatocellular carcinoma when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Hepatocellular carcinoma? *

Diarrhea: 8 people, 25.81%
Weakness: 6 people, 19.35%
Fatigue (feeling of tiredness): 5 people, 16.13%
Anaemia (lack of blood): 5 people, 16.13%
Hepatic Lesion: 4 people, 12.90%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 12.90%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 12.90%
Hospitalisation: 4 people, 12.90%
Confusional State: 3 people, 9.68%
Pneumonia: 3 people, 9.68%

What are the existing conditions these people have? *

Hepatitis C: 4 people, 12.90%
Type 2 Diabetes: 2 people, 6.45%
Gastritis (inflammation of stomach): 2 people, 6.45%
Varices Oesophageal (enlarged and swollen veins at the bottom of the oesophagus, near the stomach): 2 people, 6.45%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 1 person, 3.23%
Anaemia (lack of blood): 1 person, 3.23%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 3.23%
Cellulitis (infection under the skin): 1 person, 3.23%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 3.23%
Depression: 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Hepatocellular carcinoma?

- Check whether Hepatocellular carcinoma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,247 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatocellular carcinoma:

Hepatocellular carcinoma (306 drugs)

Browse all the conditions that are associated with Hepatocellular carcinoma:

Hepatocellular carcinoma (733 conditions)

Related publications that referenced our studies

Musri FY, Mutlu H, K?vrak Salim D, Karakurt Ery?lmaz M, ?nal B, Tural D, ?enol Co?kun H, "Sorafenib-induced severe urticaria in a patient with hepatocellular cancer", Journal of Oncology Pharmacy Practice, 2016 Jan .
Musri FY, Mutlu H, K?vrak Salim D, Karakurt Ery?lmaz M, ?nal B, Tural D, ?enol Co?kun H, "Sorafenib-induced severe urticaria in a patient with hepatocellular cancer", Journal of Oncology Pharmacy Practice, 2016 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.