Zide and Splenic infarction - a phase IV clinical study of FDA data

Summary:

Splenic infarction is reported as a side effect among people who take Zide (hydrochlorothiazide), especially for people who are male, 60+ old, also take Vitamin B12, and have Psoriatic arthropathy.

The phase IV clinical study analyzes which people have Splenic infarction when taking Zide. It is created by eHealthMe based on reports of 178,473 people who have side effects when taking Zide from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,247 Zide users. Check the latest studies of Zide.

What is Splenic infarction?

Splenic infarction (tissue damage of spleen) is found to be associated with 285 drugs and 529 conditions by eHealthMe. Check the latest studies of Splenic infarction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

178,473 people reported to have side effects when taking Zide.
Among them, 18 people (0.01%) have Splenic infarction.

Among these 18 people:

What is the gender of people who have Splenic infarction when taking Zide? *

female: 26.67 %
male: 73.33 %

What is the age of people who have Splenic infarction when taking Zide? *

What are other drugs people take besides Zide? *

What are other side effects people have besides Splenic infarction? *

Sepsis (a severe blood infection that can lead to organ failure and death): 5 people, 27.78%
Intestinal Infarction (intestinal tissue death): 4 people, 22.22%
Pleural Effusion (water on the lungs): 4 people, 22.22%
Hepatic Infarction (particular area of the liver has lost its blood supply and died): 4 people, 22.22%
Head Injury: 4 people, 22.22%
Gastric Ulcer (stomach ulcer): 4 people, 22.22%
Atelectasis (partial or complete collapse of the lung): 4 people, 22.22%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 4 people, 22.22%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 16.67%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 16.67%

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 16.67%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 2 people, 11.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 11.11%
Rashes (redness): 2 people, 11.11%
Procedural Pain: 2 people, 11.11%
Urticaria (rash of round, red welts on the skin that itch intensely): 1 person, 5.56%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 1 person, 5.56%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 5.56%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.56%
Indigestion: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and have Splenic infarction?

- Check whether Splenic infarction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zide:

Zide (183,247 reports)

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Splenic infarction:

Splenic infarction (285 drugs)

Browse all the conditions that are associated with Splenic infarction:

Splenic infarction (529 conditions)

Related publications that referenced our studies

Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .
Misgar, R. A., Bhat, J. A., Wani, A. I., & Bashir, M. I., "Sitagliptin induced splenic infarcts", Clinical Diabetology, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide (the active ingredients of Zide) and Zide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.