Zoloft and Intestinal malrotation - a phase IV clinical study of FDA data

Summary:

Intestinal malrotation is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are male, 0-1 old, have been taking the drug for 6 - 12 months also take Paxil, and have Affective disorder.

The phase IV clinical study analyzes which people have Intestinal malrotation when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,801 Zoloft users. Check the latest studies of Zoloft.

What is Intestinal malrotation?

Intestinal malrotation (congenital anomaly of rotation of the midgut) is found to be associated with 42 drugs and 86 conditions by eHealthMe. Check the latest studies of Intestinal malrotation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 13 people (0.01%) have Intestinal malrotation.

Could Zoloft cause Intestinal malrotation?

Among these 13 people:

How long have people been on Zoloft when they have Intestinal malrotation? *

What is the gender of people who have Intestinal malrotation when taking Zoloft? *

female: 45.45 %
male: 54.55 %

What is the age of people who have Intestinal malrotation when taking Zoloft? *

What are other drugs people take besides Zoloft? *

What are other side effects people have besides Intestinal malrotation? *

Maternal Exposure During Pregnancy (use of substance during pregnancy): 7 people, 53.85%
Anaemia Neonatal: 4 people, 30.77%
Respiratory Distress Syndrome (Rds) In Infants (respiratory disease of newborn babies, especially premature babies, characterized by distressful breathing, cyanosis, and the formation of a glassy membrane over the alveoli of the lungs): 4 people, 30.77%
Gastroschisis (a hole in the abdominal wall): 4 people, 30.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 30.77%
Jaundice Neonatal (yellowing of skin in neonate): 4 people, 30.77%
Foetal Growth Restriction (poor growth of a baby while in the mother's womb during pregnancy): 3 people, 23.08%
Feeding Disorder Neonatal (when newborn refuse to drink milk): 3 people, 23.08%
Infantile Apnoeic Attack (episodes where breathing stops temporarily in infant): 3 people, 23.08%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 2 people, 15.38%

What are the existing conditions these people have? *

Affective Disorder (mental disorder): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Intestinal malrotation?

- Check whether Intestinal malrotation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,801 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intestinal malrotation:

Intestinal malrotation (42 drugs)

Browse all the conditions that are associated with Intestinal malrotation:

Intestinal malrotation (86 conditions)

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.