Zoloft and Premature ejaculation - a phase IV clinical study of FDA data

Summary:

Premature ejaculation is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are 40-49 old, have been taking the drug for 10+ years also take Propecia, and have Erection problems.

The phase IV clinical study analyzes which people have Premature ejaculation when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

What is Premature ejaculation?

Premature ejaculation is found to be associated with 35 drugs and 173 conditions by eHealthMe. Check the latest studies of Premature ejaculation.

On Jul, 16, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 21 people (0.02%) have Premature ejaculation.

Could Zoloft cause Premature ejaculation?

Among these 21 people:

How long have people been on Zoloft when they have Premature ejaculation? *

What is the age of people who have Premature ejaculation when taking Zoloft? *

What are other drugs people take besides Zoloft? *

What are other side effects people have besides Premature ejaculation? *

Erection Problems: 16 people, 76.19%
Libido Decreased (loss of interest in sex): 7 people, 33.33%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 5 people, 23.81%
Hypogonadism (reduction or absence of hormone secretion or other physiological activity of the gonads (testes or ovaries)): 5 people, 23.81%
Headache (pain in head): 5 people, 23.81%
Blood Glucose Increased: 5 people, 23.81%
Nausea And Vomiting: 4 people, 19.05%
Dizziness: 4 people, 19.05%
Ejaculation Disorder: 4 people, 19.05%
Organic Erectile Dysfunction (inability to achieve or maintain an erection long enough to engage in sexual intercourse): 4 people, 19.05%

What are the existing conditions these people have? *

Erection Problems: 6 people, 28.57%
Androgenetic Alopecia (common form of hair loss): 5 people, 23.81%
Alcoholism (problems with alcohol): 3 people, 14.29%
Type 2 Diabetes: 3 people, 14.29%
Hair Loss: 2 people, 9.52%
High Blood Pressure: 2 people, 9.52%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 4.76%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 1 person, 4.76%
Joint Pain: 1 person, 4.76%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Premature ejaculation?

- Check whether Premature ejaculation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,798 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Premature ejaculation:

Premature ejaculation (35 drugs)

Browse all the conditions that are associated with Premature ejaculation:

Premature ejaculation (173 conditions)

Related publications that referenced our studies

Salama N, Eid A, Swedan A, Hatem A, "Increased prevalence of premature ejaculation in men with metabolic syndrome", The Aging Male, 2017 Feb .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Salama N, Eid A, Swedan A, Hatem A, "Increased prevalence of premature ejaculation in men with metabolic syndrome", The Aging Male, 2017 Feb .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.