Zoloft and Ra - a phase IV clinical study of FDA data

Summary:

Ra is reported as a side effect among people who take Zoloft (sertraline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humira, and have Pain.

The phase IV clinical study analyzes which people have Ra when taking Zoloft. It is created by eHealthMe based on reports of 128,159 people who have side effects when taking Zoloft from the FDA, and is updated regularly.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,792 Zoloft users. Check the latest studies of Zoloft.

What is Ra?

Ra (rheumatoid arthritis) is found to be associated with 1,613 drugs and 2,095 conditions by eHealthMe. Check the latest studies of Ra.

On Jan, 01, 2026

128,159 people reported to have side effects when taking Zoloft.
Among them, 609 people (0.48%) have Ra.

Among these 609 people:

* Approximation only. Some reports may have incomplete information.

Do you take Zoloft and have Ra?

- Check whether Ra is associated with a drug or a condition (FREE)
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zoloft:

Zoloft (138,792 reports)

Ra treatments and more:

Ra (1,091,821 reports)

How severe was Ra and when was it recovered:

Ra in Zoloft

Expand to all the drugs that have ingredients of sertraline hydrochloride:

Ra and drugs with ingredients of sertraline hydrochloride (1,396 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Zoloft side effects:

Zoloft side effect: Depression (9,096 reports)
Zoloft side effect: Pain (7,502 reports)

Browse all side effects of Zoloft:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Ra:

Enbrel side effect: Ra (61,655 reports)
Methotrexate side effect: Ra (61,185 reports)
Humira side effect: Ra (46,149 reports)
Prednisone side effect: Ra (35,759 reports)
Orencia side effect: Ra (31,786 reports)
Actemra side effect: Ra (30,529 reports)
Sulfasalazine side effect: Ra (27,331 reports)
Xeljanz side effect: Ra (26,067 reports)
Arava side effect: Ra (24,240 reports)
Leflunomide side effect: Ra (23,960 reports)

Browse all the drugs that are associated with Ra:

Ra (1,613 drugs)

Common conditions associated with Ra:

Ra: 63,567 reports
Rheumatoid arthritis: 63,498 reports
Rheumatoid arthritis aggravated: 31,122 reports
Arthritis - rheumatoid: 29,398 reports
Psoriatic arthropathy aggravated: 4,771 reports
Pain: 4,748 reports
Alternative medicine - pain relief: 4,737 reports
Hypertension: 3,683 reports
High blood pressure: 3,680 reports
Psoriasis: 3,347 reports

Browse all the conditions that are associated with Ra:

Ra (2,095 conditions)

Drugs similar to Zoloft and Ra :

Related publications that referenced our studies

Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on sertraline hydrochloride (the active ingredients of Zoloft) and Zoloft (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.