Zydone and Chest pain - a phase IV clinical study of FDA data

Summary:

Chest pain is reported as a side effect among people who take Zydone (acetaminophen; hydrocodone bitartrate), especially for people who are male, 50-59 old, also take Vioxx, and have Lumbar spine flattening.

The phase IV clinical study analyzes which people have Chest pain when taking Zydone. It is created by eHealthMe based on reports of 18,719 people who have side effects when taking Zydone from the FDA, and is updated regularly.

What is Zydone?

Zydone has active ingredients of acetaminophen; hydrocodone bitartrate. eHealthMe is studying from 18,722 Zydone users. Check the latest studies of Zydone.

What is Chest pain?

Chest pain is found to be associated with 3,461 drugs and 4,888 conditions by eHealthMe. Check the latest studies of Chest pain.

On Jul, 31, 2026

18,719 people reported to have side effects when taking Zydone.
Among them, 14 people (0.07%) have Chest pain.

Among these 14 people:

What is the gender of people who have Chest pain when taking Zydone? *

female: 42.86 %
male: 57.14 %

What is the age of people who have Chest pain when taking Zydone? *

What are other drugs people take besides Zydone? *

What are other side effects people have besides Chest pain? *

Depression: 8 people, 57.14%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 7 people, 50.00%
Heart Attack: 7 people, 50.00%
Pulmonary Oedema (fluid accumulation in the lungs): 5 people, 35.71%
High Blood Pressure: 5 people, 35.71%
Stable Angina (a constant chest pain): 5 people, 35.71%
Stent Occlusion (blockage of stent): 4 people, 28.57%
Overdose: 4 people, 28.57%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 28.57%
Narcotic Intoxication (a condition caused by use of narcotic agents): 4 people, 28.57%

What are the existing conditions these people have? *

Stomach Discomfort (pain in abdomen): 4 people, 28.57%
Pain: 4 people, 28.57%
Lumbar Spine Flattening (flatten the curve of the lower spine): 4 people, 28.57%
Burning Sensation: 2 people, 14.29%
Neck Pain: 1 person, 7.14%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Zydone and have Chest pain?

- Check whether Chest pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Zydone:

Zydone (18,722 reports)

Chest pain treatments and more:

Chest pain (363,501 reports)

How severe was Chest pain and when was it recovered:

Chest pain in Zydone

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Chest pain and drugs with ingredients of acetaminophen; hydrocodone bitartrate (7,490 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zydone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Chest pain:

Chest pain (3,461 drugs)

Browse all the conditions that are associated with Chest pain:

Chest pain (4,888 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Zydone) and Zydone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.