Tramadol vs. Ibuprofen


We compare the side effects and drug effectiveness of Tramadol and Ibuprofen. The study is created by eHealthMe based on reports of 333,585 people who take Tramadol and Ibuprofen, and is updated regularly.

What's eHealthMe?

eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. The results are readily available to health care professionals and consumers.

eHealthMe has released original studies on market drugs and worked with leading universities and institutions such as IBM, London Health Science Centre, Mayo Clinic, Northwestern University and VA. eHealthMe studies have now been referenced in over 500 peer-reviewed medical publications.

How we gather our data?

Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). This information is aggregated and used to produce personalized reports that patients can reference.

The information that eHealthMe collects includes:

  • Side effects (including severity and how people recover from them)
  • Associated conditions or symptoms
  • Drug effectiveness
  • Demographic data regarding drug use

How the study uses the data?

The study is based on tramadol hydrochloride and ibuprofen (the active ingredients of Tramadol and Ibuprofen, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 112,006 users)

What is Ibuprofen?

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from Ibuprofen 130,381 users)

How to use the study?

Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. It is recommended that patients use the information presented as a part of a broader decision-making process.

On Mar, 03, 2019

333,585 people who take Tramadol and Ibuprofen are studied.

Number of reports submitted per year:

Tramadol vs Ibuprofen drug comparison reports.

Drugs in this study:

  • Tramadol (tramadol hydrochloride)
  • Ibuprofen (ibuprofen)

Most common side effects:

  1. Drug Ineffective
  2. Nausea (feeling of having an urge to vomit)
  3. Fatigue (feeling of tiredness)
  4. Vomiting
  5. Dyspnoea (difficult or laboured respiration)
  6. Anxiety
  7. Diarrhoea
  8. Dizziness
  9. Pyrexia (fever)
  10. Arthralgia (joint pain)
  1. Nausea (feeling of having an urge to vomit)
  2. Fatigue (feeling of tiredness)
  3. Drug Ineffective
  4. Vomiting
  5. Diarrhoea
  6. Dyspnoea (difficult or laboured respiration)
  7. Dizziness
  8. Fall
  9. Arthralgia (joint pain)
  10. Asthenia (weakness)

Most common side effects experienced by people in long term use:

  1. Anxiety
  2. Nausea (feeling of having an urge to vomit)
  3. Pulmonary Embolism (blockage of the main artery of the lung)
  4. Dyspnoea (difficult or laboured respiration)
  5. Depression
  6. Emotional Distress
  7. Injury
  8. Deep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  9. Chest Pain
  10. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  1. Depression
  2. Anxiety
  3. Dizziness
  4. Fatigue (feeling of tiredness)
  5. Dyspnoea (difficult or laboured respiration)
  6. Insomnia (sleeplessness)
  7. Vomiting
  8. Chronic Kidney Disease
  9. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
  10. Suicidal Ideation

Drug effectiveness:

  • not at all: 2.95 %
  • somewhat: 25.1 %
  • moderate: 38.74 %
  • high: 25.5 %
  • very high: 7.71 %
  • not at all: 3.47 %
  • somewhat: 26.89 %
  • moderate: 41.86 %
  • high: 22.17 %
  • very high: 5.6 %

Do you take Tramadol or Ibuprofen?

You are not alone:

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WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.