Zoloft vs. Vitamin d: side effect and effectiveness comparison (a real world drug study)
Summary:
We compare the side effects and drug effectiveness of Zoloft and Vitamin d. The phase IV clinical study is created by eHealthMe based on reports (from sources including the FDA) of 608,300 people who take Zoloft and Vitamin d, and is updated regularly.
What is Zoloft?
Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.
What is Vitamin d?
Vitamin d has active ingredients of ergocalciferol. It is often used in low vitamin d. eHealthMe is studying from 294,095 Vitamin d users. Check the latest studies of Vitamin d.
608,300 people who take Zoloft and Vitamin d are studied.

Drugs being compared in this study:
- Zoloft (sertraline hydrochloride)
- Vitamin D (ergocalciferol)
Most common side effects of the drugs, overall:
Most common side effects of the drugs, in long term (1+ years) use:
Drug effectiveness:
Zoloft:
- not at all: 3.38 %
- somewhat: 19.76 %
- moderate: 36.39 %
- high: 30.27 %
- very high: 10.2 %
Vitamin D:
- not at all: 4.26 %
- somewhat: 20.83 %
- moderate: 35.12 %
- high: 29.78 %
- very high: 10.01 %
Want to compare Zoloft with Vitamin d?
- Personalize this study to your gender and age (0-99+)How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Related publications that referenced our studies
- Kapoor S, "Influence of Vitamin D Consumption and Levels on the Development of Psychiatric Disorders", Lee, Y. J., & Park, K. (2018). Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension.?Drug safety-case reports,?5(1), 7., 2014 Aug .
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
- Kapoor S, "Influence of Vitamin D Consumption and Levels on the Development of Psychiatric Disorders", Lee, Y. J., & Park, K. (2018). Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension.?Drug safety-case reports,?5(1), 7., 2014 Aug .
- Izgi C, Erdem G, Mansuroglu D, Kurtoglu N, Kara M, Gunesdogdu F, "Severe hypokalemia probably associated with sertraline use", Annals of Pharmacotherapy, 2014 Jan .
Related studies
Alternative drugs to, pros and cons of:
Browse all side effects of Zoloft:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Vitamin d:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study is based on sertraline hydrochloride and ergocalciferol (the active ingredients of Zoloft and Vitamin d, respectively). Other drugs that have the same active ingredients (e.g. generic drugs or brand names) are also considered. Dosage of drugs is not considered in the study.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
Recent studies on eHealthMe:
- Drug interactions of Januvia and Peridex - 10 seconds ago
- Could Metformin cause Costochondritis? - 10 seconds ago
- Weight Increased and drugs of ingredients of peppermint - 28 seconds ago
- Fatigue and Coronary Heart Disease - 46 seconds ago
- Acidosis and drugs of ingredients of melphalan - 49 seconds ago
- Drug interactions of Florinef and Lactulose - 51 seconds ago
- Could Hivid cause Birth Control? - 59 seconds ago
- Gingival Ulceration and drugs of ingredients of rosuvastatin calcium - a minute ago
- Aredia and Tooth Abscess for Men aged 40-49 - a minute ago
- Aredia and Tooth Infection for Men aged 40-49 - a minute ago